Anti-PIGQ Antibody (CAB17044)
- SKU:
- CAB17044
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-PIGQ Antibody |
| Antibody SKU: | CAB17044 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human PIGQ (NP_683721.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human PIGQ (NP_683721.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MVLK AFFP TCCV STDS GLLV GRWV PEQS SAVV LAVL HFPF IPIQ VKQL LAQV RQAS QVGV AVLG TWCH CRQE PEES LGRF LESL GAVF PHEP WLRL CRER GGTF WSCE ATHR QAPT APGA PGED QVML IFYD QRQV LLSQ LHLP TVLP DRQA GATT ASTG GLAA VFDT VARS EVLF RSDR FDEG PVRL SHWQ SEGV EASI |
| Gene ID: | 9091 |
| Uniprot: | Q9BRB3 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | PIGQ, GPI1, c407A10.1 |
| Background: | This gene is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | PIGQ: Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. Belongs to the PIGQ family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.4.1.198; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Transferase Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: endoplasmic reticulum membrane; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex Molecular Function:phosphatidylinositol N-acetylglucosaminyltransferase activity Biological Process: carbohydrate metabolic process; preassembly of GPI anchor in ER membrane |
| NCBI Summary: | This gene is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012] |
| UniProt Code: | Q9BRB3 |
| NCBI GenInfo Identifier: | 22538450 |
| NCBI Gene ID: | 9091 |
| NCBI Accession: | NP_004195.2 |
| UniProt Secondary Accession: | Q9BRB3,O14927, Q96G00, Q96S22, Q9UJH4, A2IDE1, D3DU52 |
| UniProt Related Accession: | Q9BRB3 |
| Molecular Weight: | 32,471 Da |
| NCBI Full Name: | phosphatidylinositol N-acetylglucosaminyltransferase subunit Q isoform 2 |
| NCBI Synonym Full Names: | phosphatidylinositol glycan anchor biosynthesis class Q |
| NCBI Official Symbol: | PIGQ |
| NCBI Official Synonym Symbols: | GPI1; c407A10.1 |
| NCBI Protein Information: | phosphatidylinositol N-acetylglucosaminyltransferase subunit Q |
| UniProt Protein Name: | Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q |
| UniProt Synonym Protein Names: | N-acetylglucosamyl transferase component GPI1; Phosphatidylinositol-glycan biosynthesis class Q protein; PIG-Q |
| Protein Family: | Phosphatidylinositol N-acetylglucosaminyltransferase |
| UniProt Gene Name: | PIGQ |
| UniProt Entry Name: | PIGQ_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PIGQ antibody (CAB17044) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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