Anti-PIDD Antibody (CAB4831)

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SKU:
CAB4831
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
PIDD1
LRDD
PIDD
Frequently bought together:

Description

Product Name:PIDD Rabbit pAb
Product Code:CAB4831
Size:20uL, 50uL, 100uL
Synonyms:PIDD1, LRDD, PIDD
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-85 of human PIDD (NP_665893.2).
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:1000 IHC 1:50 - 1:200 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, 293T, K-562, Mouse brain, Mouse liver, Mouse heart, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-85 of human PIDD (NP_665893.2).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAAT VEGP ELEA AAAA GDAS EDSD AGSR ALPF LGGN RLSL DLYP GGCQ QLLH LCVQ QPLQ LLQV EFLR LSTH EDPQ LLEA TLAQ L
Gene ID:55367
Uniprot:Q9HB75
Cellular Location:Cytoplasm, Nucleus
Calculated MW:33kDa/37kDa/58kDa/66kDa/82kDa/97kDa/99kDa
Observed MW:100-110kDa
UniProt Protein Function:PIDD: Promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. Associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. Associates with CASP2/caspase-2 and CRADD/RAIDD, and induces activation of CASP2 which an important regulator in apoptotic pathways. 7 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: Golgi apparatus; cytoplasm; nucleus

Molecular Function:protein binding; death receptor binding

Biological Process: caspase activation; positive regulation of apoptosis; signal transduction; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; response to DNA damage stimulus; negative regulation of apoptosis; activation of NF-kappaB transcription factor

NCBI Summary:The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]
UniProt Code:Q9HB75
NCBI GenInfo Identifier:116242715
NCBI Gene ID:55367
NCBI Accession:Q9HB75.2
UniProt Related Accession:Q9HB75
Molecular Weight:~ 100-110kDa
NCBI Full Name:p53-induced death domain-containing protein 1
NCBI Synonym Full Names:p53-induced death domain protein 1
NCBI Official Symbol:PIDD1  
NCBI Official Synonym Symbols:LRDD; PIDD  
NCBI Protein Information:p53-induced death domain-containing protein 1
UniProt Protein Name:p53-induced death domain-containing protein 1
UniProt Synonym Protein Names:Leucine-rich repeat and death domain-containing protein
UniProt Gene Name:PIDD1  
UniProt Entry Name:PIDD1_HUMAN

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