Anti-PI3 Kinase p110 beta Antibody (CAB0982)
- SKU:
- CAB0982
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Autophagy
Frequently bought together:
Description
| Antibody Name: | Anti-PI3 Kinase p110 beta Antibody |
| Antibody SKU: | CAB0982 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 771-1070 of human PI3 Kinase p110 beta (NP_006210.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 771-1070 of human PI3 Kinase p110 beta (NP_006210.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LYVE KCKY MDSK MKPL WLVY NNKV FGED SVGV IFKN GDDL RQDM LTLQ MLRL MDLL WKEA GLDL RMLP YGCL ATGD RSGL IEVV STSE TIAD IQLN SSNV AAAA AFNK DALL NWLK EYNS GDDL DRAI EEFT LSCA GYCV ASYV LGIG DRHS DNIM VKKT GQLF HIDF GHIL GNFK SKFG IKRE RVPF ILTY DFIH VIQQ GKTG NTEK FGRF RQCC EDAY LILR RHGN LFIT LFAL MLTA GLPE LTSV KDIQ YLKD SLAL GKSE EEAL KQFK QKFD EALR ESWT TKVN WMAH TVRK DYRS |
| Gene ID: | 5291 |
| Uniprot: | P42338 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 122kDa |
| Observed MW: | 123KDa |
| Synonyms: | PIK3CB, P110BETA, PI3K, PI3KBETA, PIK3C1 |
| Background: | This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | PIK3CB: catalytic subunit of phosphoinositide-3-kinase beta. Catalyzes the production of phosphatidylinositol-3,4,5-triphosphate by phosphorylating phosphatidylinositol (PI), phosphatidylinositol-4-phosphate (PIP) and phosphatidylinositol-4,5-bisphosphate (PIP2). Growth factors and hormones trigger this phosphorylation event, which in turn coordinates cell growth, cell cycle entry, cell migration and cell survival. PTEN reverses this process, and the PI3K signaling pathway is constitutively activated in human cancers that have loss of function of PTEN. Expressed ubiquitously. |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - inositol phosphate; Motility/polarity/chemotaxis; EC 2.7.1.153; Kinase, lipid Chromosomal Location of Human Ortholog: 3q22.3 Cellular Component: cytosol; intercellular bridge; nucleolus; nucleus; phosphoinositide 3-kinase complex; plasma membrane Molecular Function:1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphatidylinositol-4-phosphate 3-kinase activity; phosphoinositide 3-kinase activity; protein binding Biological Process: activation of MAPK activity; cell migration; chemotaxis; G-protein coupled receptor protein signaling pathway; leukocyte migration; phosphatidylinositol biosynthetic process; phosphoinositide 3-kinase cascade; phosphoinositide-mediated signaling; platelet activation; positive regulation of autophagy; regulation of cell-matrix adhesion; regulation of phosphoinositide 3-kinase cascade; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway |
| NCBI Summary: | This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011] |
| UniProt Code: | P42338 |
| NCBI GenInfo Identifier: | 1171955 |
| NCBI Gene ID: | 5291 |
| NCBI Accession: | P42338.1 |
| UniProt Secondary Accession: | P42338,Q24JU2, D3DNF0, |
| UniProt Related Accession: | P42338 |
| Molecular Weight: | 122,762 Da |
| NCBI Full Name: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform |
| NCBI Synonym Full Names: | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| NCBI Official Symbol: | PIK3CB |
| NCBI Official Synonym Symbols: | PI3K; PIK3C1; P110BETA; PI3KBETA |
| NCBI Protein Information: | phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform |
| UniProt Protein Name: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform |
| UniProt Synonym Protein Names: | Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; PtdIns-3-kinase subunit p110-beta; p110beta |
| Protein Family: | Phosphatidylinositol 4,5-bisphosphate 3-kinase |
| UniProt Gene Name: | PIK3CB |
| UniProt Entry Name: | PK3CB_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PI3 Kinase p110 beta Rabbit pAb (CAB0982) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded mouse lung using PI3 Kinase p110 beta antibody (CAB0982) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human lung using PI3 Kinase p110 beta antibody (CAB0982) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using PI3 Kinase p110 beta antibody (CAB0982) at dilution of 1:100 (40x lens). |
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