Anti-Phospho-MLKL-S441 Antibody (CABP1174)

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SKU:
CABP1174
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
MLKL
hMLKL
mixed lineage kinase domain-like protein
Frequently bought together:

Description

Product Name:Phospho-MLKL-S441 Rabbit pAb
Product Code:CABP1174
Size:20uL, 50uL, 100uL
Synonyms:MLKL, hMLKL, mixed lineage kinase domain-like protein
Applications:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:A phospho synthetic peptide corresponding to residues surrounding S441 of Mouse MLKL.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Rat
Positive Samples:C6
Immunogen:A phospho synthetic peptide corresponding to residues surrounding S441 of Mouse MLKL.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:74568
Uniprot:Q9D2Y4
Cellular Location:Cell membrane, Cytoplasm
Calculated MW:53kDa/54kDa
Observed MW:54KDa
UniProt Protein Function:MLKL: Belongs to the protein kinase superfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; TKL group; TKL-Unique family Cellular Component: membrane; cytoplasm; plasma membrane Molecular Function: transferase activity, transferring phosphorus-containing groups; protein complex binding; nucleotide binding; protein kinase binding; ATP binding; protein kinase activity Biological Process: programmed cell death; protein amino acid phosphorylation
UniProt Protein Details:
NCBI Summary:This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential for necroptosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
UniProt Code:Q9D2Y4
NCBI GenInfo Identifier:81916976
NCBI Gene ID:74568
NCBI Accession:Q9D2Y4.1
UniProt Secondary Accession:Q9D2Y4,Q8CIJ5
UniProt Related Accession:Q9D2Y4
Molecular Weight:54kDa
NCBI Full Name:Mixed lineage kinase domain-like protein
NCBI Synonym Full Names:mixed lineage kinase domain-like
NCBI Official Symbol:Mlkl  
NCBI Official Synonym Symbols:9130019I15Rik  
NCBI Protein Information:mixed lineage kinase domain-like protein; mlkl
UniProt Protein Name:Mixed lineage kinase domain-like protein
UniProt Synonym Protein Names:
Protein Family:Mixed lineage kinase domain-like protein
UniProt Gene Name:Mlkl  
UniProt Entry Name:MLKL_MOUSE

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