Anti-PHC3 Antibody (CAB6479)
- SKU:
- CAB6479
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-PHC3 Antibody |
| Antibody SKU: | CAB6479 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human PHC3 (NP_079223.3). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, A-549, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human PHC3 (NP_079223.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LSSS QLQS LAAV QASL SSGR PSTS PTGS VTQQ SSMS QTSI NLST SPTP AQLI SRSQ ASSS TSGS ITQQ TMLL GSTS PTLT ASQA QMYL RAQM LIFT PATT VAAV QSDI PVVS SSSS SSCQ SAAT QVQN LTLR SQKL GVLS SSQN GPPK STSQ TQSL TICH NKTT VTSS KISQ RDPS PESN KKGE SPSL ESRS TAVT RTSS I |
| Gene ID: | 80012 |
| Uniprot: | Q8NDX5 |
| Cellular Location: | Nucleus |
| Calculated MW: | 14kDa/16kDa/19kDa/35kDa/104kDa/106kDa/107kDa |
| Observed MW: | 106kDa |
| Synonyms: | PHC3, EDR3, HPH3 |
| Background: |
| UniProt Protein Function: | PHC3: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. 7 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription regulation Chromosomal Location of Human Ortholog: 3q26.2 Cellular Component: actin cytoskeleton; intracellular membrane-bound organelle; nucleoplasm; nucleus; PcG protein complex Molecular Function:protein binding Biological Process: protein sumoylation |
| UniProt Code: | Q8NDX5 |
| NCBI GenInfo Identifier: | 74715388 |
| NCBI Gene ID: | 80012 |
| NCBI Accession: | Q8NDX5.1 |
| UniProt Secondary Accession: | Q8NDX5,Q5HYF0, Q6NSG2, Q8NFT7, Q8NFZ1, Q8TBM2, Q9H971 Q9H9I4, A2RRP9, |
| UniProt Related Accession: | Q8NDX5 |
| Molecular Weight: | 107,480 Da |
| NCBI Full Name: | Polyhomeotic-like protein 3 |
| NCBI Synonym Full Names: | polyhomeotic homolog 3 |
| NCBI Official Symbol: | PHC3 |
| NCBI Official Synonym Symbols: | EDR3; HPH3 |
| NCBI Protein Information: | polyhomeotic-like protein 3 |
| UniProt Protein Name: | Polyhomeotic-like protein 3 |
| UniProt Synonym Protein Names: | Early development regulatory protein 3; Homolog of polyhomeotic 3; hPH3 |
| Protein Family: | Polyhomeotic-like protein |
| UniProt Gene Name: | PHC3 |
| UniProt Entry Name: | PHC3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PHC3 Antibody (CAB6479) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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