Anti-PGC1alpha Antibody (CAB12348)

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SKU:
CAB12348
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
PPARGC1A
LEM6
PGC-1(alpha)
PGC-1alpha
PGC-1v
PGC1
PGC1A
PPARGC1
PPARG coactivator 1 alpha
PGC1 alpha
Frequently bought together:

Description

Product Name:PGC1? Rabbit pAb
Product Code:CAB12348
Size:20uL, 50uL, 100uL
Synonyms:PPARGC1A, LEM6, PGC-1(alpha), PGC-1alpha, PGC-1v, PGC1, PGC1A, PPARGC1, PPARG coactivator 1 alpha, PGC1 alpha
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 700 to the C-terminus of human PGC1? (NP_037393.1).
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse heart, Rat heart
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 700 to the C-terminus of human PGC1? (NP_037393.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FGEI EECT VNLR DDGD SYGF ITYR YTCD AFAA LENG YTLR RSNE TDFE LYFC GRKQ FFKS NYAD LDSN SDDF DPAS TKSK YDSL DFDS LLKE AQRS LRR
Gene ID:10891
Uniprot:Q9UBK2
Cellular Location:Cytoplasm, Nucleus, PML body
Calculated MW:14kDa/30kDa/31kDa/33kDa/77kDa/89kDa/91kDa
Observed MW:91KDa
UniProt Protein Function:PGC-1 alpha: a transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor genes. Interacts with, and regulates the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). Regulates many genes involved in energy metabolism. Provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. May be involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. Its transcription is repressed by ZNF746 which binds to 'insulin response sequences' in its promoter. Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions.
UniProt Protein Details:

Protein type:Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 4p15.2

Cellular Component: DNA-directed RNA polymerase II, core complex; intracellular membrane-bound organelle; nucleoplasm; nucleus

Molecular Function:chromatin DNA binding; DNA binding; ligand-dependent nuclear receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; protein binding; RNA binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor binding; ubiquitin protein ligase binding

Biological Process: brown fat cell differentiation; cellular respiration; circadian regulation of gene expression; circadian rhythm; digestion; mitochondrion organization and biogenesis; mRNA processing; negative regulation of neuron apoptosis; positive regulation of fatty acid oxidation; positive regulation of gluconeogenesis; positive regulation of histone acetylation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein complex assembly; protein stabilization; regulation of circadian rhythm; regulation of transcription, DNA-dependent; response to muscle activity; RNA splicing; thermoregulation; transcription initiation from RNA polymerase II promoter

NCBI Summary:The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UBK2
NCBI GenInfo Identifier:47117335
NCBI Gene ID:10891
NCBI Accession:Q9UBK2.1
UniProt Secondary Accession:Q9UBK2,Q3LIG1, Q4W5M7, Q9UN32, B7Z406, G8DM16, I3RTT5 I3RTT6, I3RTT7, I3RTT8, I3RTT9,
UniProt Related Accession:Q9UBK2
Molecular Weight:91kDa
NCBI Full Name:Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
NCBI Synonym Full Names:PPARG coactivator 1 alpha
NCBI Official Symbol:PPARGC1A  
NCBI Official Synonym Symbols:LEM6; PGC1; PGC1A; PGC-1v; PPARGC1; PGC-1alpha; PGC-1(alpha)  
NCBI Protein Information:peroxisome proliferator-activated receptor gamma coactivator 1-alpha
UniProt Protein Name:Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
UniProt Synonym Protein Names:Ligand effect modulator 6
Protein Family:Peroxisome proliferator-activated receptor gamma coactivator
UniProt Gene Name:PPARGC1A  

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