Anti-PGAM5 Antibody (CAB16022)

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SKU:
CAB16022
Product type:
Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
Frequently bought together:

Description

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Antibody Name:Anti-PGAM5 Antibody
Antibody SKU:CAB16022
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 30-225 of human PGAM5 (NP_612642.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Rat liver, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 30-225 of human PGAM5 (NP_612642.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:KPRA GGDA EPRP AEPP AWAG GARP GPGV WDPN WDRR EPLS LINV RKRN VESG EEEL ASKL DHYK AKAT RHIF LIRH SQYH VDGS LEKD RTLT PLGR EQAE LTGL RLAS LGLK FNKI VHSS MTRA IETT DIIS RHLP GVCK VSTD LLRE GAPI EPDP PVSH WKPE AVQY YEDG ARIE AAFR NYIH RADA RQEE DSYE
Gene ID:192111
Uniprot:Q96HS1
Cellular Location:
Calculated MW:28kDa/32kDa
Observed MW:32kDa
Synonyms:PGAM5, BXLBV68
Background:
UniProt Protein Function:PGAM5: Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression. Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Hydrolase; EC 3.1.3.16; Mitochondrial

Chromosomal Location of Human Ortholog: 12q24.33

Cellular Component: integral to membrane; mitochondrial outer membrane; mitochondrion

Molecular Function:GTPase activator activity; phosphoric monoester hydrolase activity; protein complex binding; receptor signaling protein serine/threonine phosphatase activity

Biological Process: dephosphorylation; positive regulation of GTPase activity; protein amino acid dephosphorylation

UniProt Code:Q96HS1
NCBI GenInfo Identifier:281604151
NCBI Gene ID:192111
NCBI Accession:NP_612642.2
UniProt Secondary Accession:Q96HS1,Q96JB0, A9LN06, C9IZY7,
UniProt Related Accession:Q96HS1
Molecular Weight:28,020 Da
NCBI Full Name:serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 3
NCBI Synonym Full Names:PGAM family member 5, mitochondrial serine/threonine protein phosphatase
NCBI Official Symbol:PGAM5  
NCBI Official Synonym Symbols:BXLBV68  
NCBI Protein Information:serine/threonine-protein phosphatase PGAM5, mitochondrial
UniProt Protein Name:Serine/threonine-protein phosphatase PGAM5, mitochondrial
UniProt Synonym Protein Names:Bcl-XL-binding protein v68; Phosphoglycerate mutase family member 5
Protein Family:Serine/threonine-protein phosphatase
UniProt Gene Name:PGAM5  
UniProt Entry Name:PGAM5_HUMAN
Anti-PGAM5 Antibody (CAB16022)Western blot analysis of extracts of various cell lines, using PGAM5 antibody (CAB16022) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

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