Anti-PGA3 Antibody (CAB17321)
- SKU:
- CAB17321
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-PGA3 Antibody |
| Antibody SKU: | CAB17321 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 63-180 of human PGA3 (NP_001073275.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | C6, U-251MG, U-87MG, SGC-7901, Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 63-180 of human PGA3 (NP_001073275.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VDEQ PLEN YLDM EYFG TIGI GTPA QDFT VVFD TGSS NLWV PSVY CSSL ACTN HNRF NPED SSTY QSTS ETVS ITYG TGSM TGIL GYDT VQVG GISD TNQI FGLS ETEP GSFL YYAP FD |
| Gene ID: | 643834 |
| Uniprot: | P0DJD8 |
| Cellular Location: | Secreted |
| Calculated MW: | 41kDa |
| Observed MW: | 42kDa |
| Synonyms: | PGA3 |
| Background: | This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. |
| UniProt Protein Function: | PGA3: Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. Belongs to the peptidase A1 family. |
| UniProt Protein Details: | Protein type:EC 3.4.23.1; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 11q12.2 Molecular Function:aspartic-type endopeptidase activity Biological Process: digestion; proteolysis |
| NCBI Summary: | This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015] |
| UniProt Code: | P0DJD8 |
| NCBI GenInfo Identifier: | 378521956 |
| NCBI Gene ID: | 643834 |
| NCBI Accession: | P0DJD8.1 |
| UniProt Related Accession: | P0DJD8 |
| Molecular Weight: | |
| NCBI Full Name: | Pepsin A-3 |
| NCBI Synonym Full Names: | pepsinogen 3, group I (pepsinogen A) |
| NCBI Official Symbol: | PGA3 |
| NCBI Protein Information: | pepsin A-3 |
| UniProt Protein Name: | Pepsin A-3 |
| UniProt Synonym Protein Names: | Pepsinogen-3 |
| UniProt Gene Name: | PGA3 |
| UniProt Entry Name: | PEPA3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PGA3 antibody (CAB17321) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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