Anti-Peroxiredoxin 2 Antibody (CAB4308)
- SKU:
- CAB4308
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-Peroxiredoxin 2 Antibody |
| Antibody SKU: | CAB4308 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Peroxiredoxin 2 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, K-562, SH-SY5Y, Mouse brain, Mouse heart, Rat brain, Rat spleen, Rat heart |
| Immunogen: | A synthesized peptide derived from human Peroxiredoxin 2 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 7001 |
| Uniprot: | P32119 |
| Cellular Location: | |
| Calculated MW: | 22kDa |
| Observed MW: | 22KDa |
| Synonyms: | HEL-S-2a, NKEF-B, NKEFB, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA |
| Background: | This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013] |
| UniProt Protein Function: | PRDX2: a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). May have a proliferative effect and play a role in cancer development or progression. Three splice-variant isoforms have been identified. |
| UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.11.1.15 Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: cytoplasm; cytosol Molecular Function:antioxidant activity; thioredoxin peroxidase activity Biological Process: regulation of apoptosis; response to reactive oxygen species; removal of superoxide radicals; hydrogen peroxide catabolic process; response to oxidative stress; negative regulation of neuron apoptosis; negative regulation of apoptosis |
| NCBI Summary: | This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013] |
| UniProt Code: | P32119 |
| NCBI GenInfo Identifier: | 2507169 |
| NCBI Gene ID: | 7001 |
| NCBI Accession: | P32119.5 |
| UniProt Secondary Accession: | P32119,P31945, P32118, P35701, Q6FHG4, Q92763, Q9UC23 A8K0C0, |
| UniProt Related Accession: | P32119 |
| Molecular Weight: | 198 |
| NCBI Full Name: | Peroxiredoxin-2 |
| NCBI Synonym Full Names: | peroxiredoxin 2 |
| NCBI Official Symbol: | PRDX2 |
| NCBI Official Synonym Symbols: | PRP; TSA; PRX2; PTX1; TPX1; NKEFB; PRXII; TDPX1; NKEF-B; HEL-S-2a |
| NCBI Protein Information: | peroxiredoxin-2; torin; thioredoxin peroxidase 1; thiol-specific antioxidant 1; natural killer cell-enhancing factor B; thioredoxin-dependent peroxide reductase 1; epididymis secretory sperm binding protein Li 2a |
| UniProt Protein Name: | Peroxiredoxin-2 |
| UniProt Synonym Protein Names: | Natural killer cell-enhancing factor B; NKEF-B; PRP; Thiol-specific antioxidant protein; TSA; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1 |
| Protein Family: | Peroxiredoxin |
| UniProt Gene Name: | PRDX2 |
| UniProt Entry Name: | PRDX2_HUMAN |
 | Western blot - Peroxiredoxin 2 Rabbit mAb (CAB4308) |
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