Anti-Pepsinogen II Antibody (CAB2788)
- SKU:
- CAB2788
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-Pepsinogen II Antibody |
| Antibody SKU: | CAB2788 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human Pepsinogen II (NP_001159896.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse liver, Mouse heart, Rat liver |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human Pepsinogen II (NP_001159896.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PSVY CQSQ ACTS HSRF NPSE SSTY STNG QTFS LQYG SGSL TGFF GYDT LTVQ SIQV PNQE FGLS ENEP GTNF VYAQ FDGI MGLA YPAL SVDE ATTA MQGM V |
| Gene ID: | 5225 |
| Uniprot: | P20142 |
| Cellular Location: | Secreted |
| Calculated MW: | 34kDa/42kDa |
| Observed MW: | 45-50kDa |
| Synonyms: | PGC, PEPC, PGII, gastricsin |
| Background: | This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. |
| UniProt Protein Function: | PGC: Hydrolyzes a variety of proteins. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Protease; Secreted; EC 3.4.23.3 Chromosomal Location of Human Ortholog: 6p21.1 Cellular Component: extracellular space Molecular Function:aspartic-type endopeptidase activity Biological Process: digestion; proteolysis |
| NCBI Summary: | This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009] |
| UniProt Code: | P20142 |
| NCBI GenInfo Identifier: | 129796 |
| NCBI Gene ID: | 5225 |
| NCBI Accession: | P20142.1 |
| UniProt Secondary Accession: | P20142,Q5T3D7, Q5T3D8, B4DVZ3, |
| UniProt Related Accession: | P20142 |
| Molecular Weight: | 40,600 |
| NCBI Full Name: | Gastricsin |
| NCBI Synonym Full Names: | progastricsin (pepsinogen C) |
| NCBI Official Symbol: | PGC |
| NCBI Official Synonym Symbols: | PEPC; PGII |
| NCBI Protein Information: | gastricsin; pepsin C; pepsinogen C; preprogastricsin; pepsinogen group II |
| UniProt Protein Name: | Gastricsin |
| UniProt Synonym Protein Names: | Pepsinogen C |
| Protein Family: | Gastricsin |
| UniProt Gene Name: | PGC |
| UniProt Entry Name: | PEPC_HUMAN |
 | Western blot analysis of extracts of various cell lines, using Pepsinogen II antibody (CAB2788) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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