Anti-PDX1 Antibody (CAB3070)
- SKU:
- CAB3070
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| Antibody Name: | Anti-PDX1 Antibody |
| Antibody SKU: | CAB3070 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human PDX1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse intestine |
| Immunogen: | A synthetic peptide of human PDX1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3651 |
| Uniprot: | P52945 |
| Cellular Location: | Cytoplasm, Nucleus, cytosol |
| Calculated MW: | 30kDa |
| Observed MW: | 34kDa |
| Synonyms: | PDX1, GSF, IDX-1, IPF1, IUF1, MODY4, PAGEN1, PDX-1, STF-1 |
| Background: | The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). |
| UniProt Protein Function: | PDX1: Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. Interacts with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). Interacts with SPOP. Interacts with the methyltransferase SETD7. Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells). Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 13q12.1 Molecular Function:transcription factor activity Biological Process: detection of glucose; generation of precursor metabolites and energy; insulin secretion; nitric oxide mediated signal transduction; organ morphogenesis; positive regulation of transcription from RNA polymerase II promoter Disease: Diabetes Mellitus, Noninsulin-dependent; Diabetes Mellitus, Permanent Neonatal; Maturity-onset Diabetes Of The Young, Type 4; Pancreatic Agenesis 1 |
| NCBI Summary: | The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Jul 2008] |
| UniProt Code: | P52945 |
| NCBI GenInfo Identifier: | 1708540 |
| NCBI Gene ID: | 3651 |
| NCBI Accession: | P52945.1 |
| UniProt Secondary Accession: | P52945,O60594, Q5VYW2, |
| UniProt Related Accession: | P52945 |
| Molecular Weight: | 30,771 Da |
| NCBI Full Name: | Pancreas/duodenum homeobox protein 1 |
| NCBI Synonym Full Names: | pancreatic and duodenal homeobox 1 |
| NCBI Official Symbol: | PDX1 |
| NCBI Official Synonym Symbols: | GSF; IPF1; IUF1; IDX-1; MODY4; PDX-1; STF-1; PAGEN1 |
| NCBI Protein Information: | pancreas/duodenum homeobox protein 1 |
| UniProt Protein Name: | Pancreas/duodenum homeobox protein 1 |
| UniProt Synonym Protein Names: | Glucose-sensitive factor; GSF; Insulin promoter factor 1; IPF-1; Insulin upstream factor 1; IUF-1; Islet/duodenum homeobox-1; IDX-1; Somatostatin-transactivating factor 1; STF-1 |
| Protein Family: | Pyridoxal 5'-phosphate synthase |
| UniProt Gene Name: | PDX1 |
| UniProt Entry Name: | PDX1_HUMAN |
 | Western blot analysis of extracts of mouse intestine, using PDX1 antibody (CAB3070) at 1:400 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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