Anti-PDP2 Antibody (CAB17190)
- SKU:
- CAB17190
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-PDP2 Antibody |
| Antibody SKU: | CAB17190 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 67-250 of human PDP2 (NP_065837.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse heart, Mouse skeletal muscle, Rat heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 67-250 of human PDP2 (NP_065837.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | STEE DDFH LQLS PEQI NEVL RAGE TTHK ILDL ESRV PNSV LRFE SNQL AANS PVED RRGV ASCL QTNG LMFG IFDG HGGH ACAQ AVSE RLFY YVAV SLMS HQTL EHME GAME SMKP LLPI LHWL KHPG DSIY KDVT SVHL DHLR VYWQ ELLD LHME MGLS IEEA LMYS FQRL DSDI SLEI QAPL |
| Gene ID: | 57546 |
| Uniprot: | Q9P2J9 |
| Cellular Location: | |
| Calculated MW: | 59kDa |
| Observed MW: | 50kDa |
 | Western blot - PDP2 Polyclonal Antibody (CAB17190) |
| Synonyms: | PDP2, PDPC 2, PPM2B, PPM2C2 |
| Background: | This gene is a mitochondrial protein that functions as a phosphatase and is involved in the enzymatic resetting of the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants encoding the same protein. |
| UniProt Protein Function: | PDP2: a protein phosphoserine phosphatase associated with the mitochondrial matrix that activates phosphorylated pyruvate dehydrogenase complex by dephosphorylation. The PDPs play crucial roles in switching metabolic flux from glycolysis towards oxidative phosphorylation. Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. PDP2 consists of only a catalytic subunit. Belongs to the PP2C family. |
| UniProt Protein Details: | Protein type:EC 3.1.3.43; Protein phosphatase, Ser/Thr (non-receptor); Mitochondrial Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: mitochondrial matrix Molecular Function:[pyruvate dehydrogenase (lipoamide)] phosphatase activity; metal ion binding; magnesium-dependent protein serine/threonine phosphatase activity Biological Process: cellular metabolic process; regulation of acetyl-CoA biosynthetic process from pyruvate; pyruvate metabolic process |
| UniProt Code: | Q9P2J9 |
| NCBI GenInfo Identifier: | 41349497 |
| NCBI Gene ID: | 57546 |
| NCBI Accession: | NP_065837.1 |
| UniProt Secondary Accession: | Q9P2J9,A8K924, |
| UniProt Related Accession: | Q9P2J9 |
| Molecular Weight: | 59,978 Da |
| NCBI Full Name: | [Pyruvate dehydrogenase |
| NCBI Synonym Full Names: | pyruvate dehyrogenase phosphatase catalytic subunit 2 |
| NCBI Official Symbol: | PDP2 |
| NCBI Official Synonym Symbols: | PPM2C2 |
| NCBI Protein Information: | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial |
| UniProt Protein Name: | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial |
| UniProt Synonym Protein Names: | Pyruvate dehydrogenase phosphatase catalytic subunit 2; PDPC 2 |
| Protein Family: | PWWP domain-containing protein |
| UniProt Gene Name: | PDP2 |
| UniProt Entry Name: | PDP2_HUMAN |
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