| Background: | The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| UniProt Protein Function: | PDE7A: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction. Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nucleotide Metabolism - purine; Phosphodiesterase; EC 3.1.4.53 Chromosomal Location of Human Ortholog: 8q13 Cellular Component: cytosol Molecular Function:3',5'-cyclic-AMP phosphodiesterase activity |
| NCBI Summary: | The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011] |
| UniProt Code: | Q13946 |
| NCBI GenInfo Identifier: | 3182958 |
| NCBI Gene ID: | 5150 |
| NCBI Accession: | Q13946.2 |
| UniProt Secondary Accession: | Q13946,O15380, Q96T72, A0AVH6, A8K436, A8K9G5, |
| UniProt Related Accession: | Q13946 |
| Molecular Weight: | 48,828 Da |
| NCBI Full Name: | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
| NCBI Synonym Full Names: | phosphodiesterase 7A |
| NCBI Official Symbol: | PDE7A |
| NCBI Official Synonym Symbols: | HCP1; PDE7 |
| NCBI Protein Information: | high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
| UniProt Protein Name: | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
| UniProt Synonym Protein Names: | HCP1; TM22 |
| Protein Family: | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase |
| UniProt Gene Name: | PDE7A |
| UniProt Entry Name: | PDE7A_HUMAN |
