Anti-PDE6G Antibody (CAB17516)

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SKU:
CAB17516
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Frequently bought together:

Description

system_update_alt데이터시트system_update_alt안전 데이터시트
Antibody Name:Anti-PDE6G Antibody
Antibody SKU:CAB17516
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-87 of human PDE6G (NP_002593.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse liver, Mouse eye, Rat spleen
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-87 of human PDE6G (NP_002593.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MNLE PPKA EFRS ATRV AGGP VTPR KGPP KFKQ RQTR QFKS KPPK KGVQ GFGD DIPG MEGL GTDI TVIC PWEA FNHL ELHE LAQY GII
Gene ID:5148
Uniprot:P18545
Cellular Location:
Calculated MW:
Observed MW:13kDa
Anti-PDE6G Antibody (CAB17516)Western blot - PDE6G Polyclonal Antibody (CAB17516)
Synonyms:PDEG, RP57, PDE6G
Background:This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]
UniProt Protein Function:PDE6G: inhibitory gamma subunit of the retinal photoreceptor type 6 cGMP phosphodiesterase (PDE-gamma). Phosphorylated by GRK2. Regulates EGFR dependent stimulation of ERK1/2. Forms a cellular complex with src. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. Participates in processes of transmission and amplification of the visual signal.
UniProt Protein Details:

Protein type:EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: plasma membrane

Molecular Function:enzyme inhibitor activity; protein binding

Biological Process: regulation of rhodopsin mediated signaling; rhodopsin mediated signaling; Wnt receptor signaling pathway, calcium modulating pathway

Disease: Retinitis Pigmentosa; Retinitis Pigmentosa 57

NCBI Summary:This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]
UniProt Code:P18545
NCBI GenInfo Identifier:4505673
NCBI Gene ID:5148
NCBI Accession:NP_002593.1
UniProt Secondary Accession:P18545,Q3KP63, Q7Z3U8,
UniProt Related Accession:P18545
Molecular Weight:9,643 Da
NCBI Full Name:retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
NCBI Synonym Full Names:phosphodiesterase 6G
NCBI Official Symbol:PDE6G  
NCBI Official Synonym Symbols:PDEG; RP57  
NCBI Protein Information:retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
UniProt Protein Name:Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Protein Family:Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase
UniProt Gene Name:PDE6G  
UniProt Entry Name:CNRG_HUMAN

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