Anti-PDE10A Antibody (CAB15597)
- SKU:
- CAB15597
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-PDE10A Antibody |
| Antibody SKU: | CAB15597 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-200 of human PDE10A (NP_001124162.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-200 of human PDE10A (NP_001124162.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SLTD EKVK AYLS LHPQ VLDE FVSE SVSA ETVE KWLK RKNN KSED ESAP KEVS RYQD TNMQ GVVY ELNS YIEQ RLDT GGDN QLLL YELS SIIK IATK ADGF ALYF LGEC NNSL CIFT PPGI KEGK PRLI PAGP ITQG TTVS AYVA KSRK TLLV EDIL GDER FPRG TGLE SGTR IQSV LC |
| Gene ID: | 10846 |
| Uniprot: | Q9Y233 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 88kDa/89kDa |
| Observed MW: | 88kDa |
| Synonyms: | PDE10A, ADSD2, HSPDE10A, IOLOD, LINC00473, PDE10A19 |
| Background: | The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. |
| UniProt Protein Function: | PDE10A: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. Belongs to the cyclic nucleotide phosphodiesterase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nucleotide Metabolism - purine; Phosphodiesterase; EC 3.1.4.17; EC 3.1.4.35 Chromosomal Location of Human Ortholog: 6q26 Cellular Component: cytosol Molecular Function:3',5'-cyclic-GMP phosphodiesterase activity; metal ion binding; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; cGMP binding; cAMP binding; 3',5'-cyclic-nucleotide phosphodiesterase activity Biological Process: cAMP catabolic process; cGMP catabolic process; blood coagulation; signal transduction |
| NCBI Summary: | The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q9Y233 |
| NCBI GenInfo Identifier: | 7993747 |
| NCBI Gene ID: | 10846 |
| NCBI Accession: | Q9Y233.1 |
| UniProt Secondary Accession: | Q9Y233,Q6FHX1, Q9HCP9, Q9NTV4, Q9ULW9, Q9Y5T1, |
| UniProt Related Accession: | Q9Y233 |
| Molecular Weight: | 89,390 Da |
| NCBI Full Name: | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
| NCBI Synonym Full Names: | phosphodiesterase 10A |
| NCBI Official Symbol: | PDE10A |
| NCBI Official Synonym Symbols: | HSPDE10A |
| NCBI Protein Information: | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; dJ416F21.1 (phosphodiesterase 10A); phosphodiesterase 10A1 (PDE10A1) |
| UniProt Protein Name: | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
| Protein Family: | cGMP-gated cation channel |
| UniProt Gene Name: | PDE10A |
| UniProt Entry Name: | PDE10_HUMAN |
 | Western blot analysis of extracts of rat brain, using PDE10A antibody (CAB15597) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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