Anti-PD-1 Antibody (CAB11973)
- SKU:
- CAB11973
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
Antibody Name: | Anti-PD-1 Antibody |
Antibody SKU: | CAB11973 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IHC IF |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PD-1 (NP_005009.2). |
Application: | WB IHC IF |
Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | Raji, Mouse spleen, Mouse thymus, Rat thymus |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PD-1 (NP_005009.2). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | MQIP QAPW PVVW AVLQ LGWR PGWF LDSP DRPW NPPT FSPA LLVV TEGD NATF TCSF SNTS ESFV LNWY RMSP SNQT DKLA AFPE DRSQ PGQD CRFR VTQL |
Gene ID: | 5133 |
Uniprot: | Q15116 |
Cellular Location: | Membrane, Single-pass type I membrane protein |
Calculated MW: | 31kDa |
Observed MW: | 40-70kDa |
Synonyms: | PDCD1, CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1 |
Background: | This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. |
UniProt Protein Function: | Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors. |
NCBI Summary: | This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q15116 |
NCBI GenInfo Identifier: | 145559515 |
NCBI Gene ID: | 5133 |
NCBI Accession: | Q15116.3 |
UniProt Secondary Accession: | Q15116,Q02242, |
UniProt Related Accession: | Q15116 |
Molecular Weight: | |
NCBI Full Name: | Programmed cell death protein 1 |
NCBI Synonym Full Names: | programmed cell death 1 |
NCBI Official Symbol: | PDCD1 |
NCBI Official Synonym Symbols: | PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1 |
NCBI Protein Information: | programmed cell death protein 1 |
UniProt Protein Name: | Programmed cell death protein 1 |
UniProt Synonym Protein Names: | CD_antigen: CD279 |
UniProt Gene Name: | PDCD1 |