Anti-PCSK5 Antibody (CAB5450)
- SKU:
- CAB5450
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| Antibody Name: | Anti-PCSK5 Antibody |
| Antibody SKU: | CAB5450 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 601-913 of human PCSK5 (NP_006191.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Jurkat, SW480, Mouse lung, Rat lung, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 601-913 of human PCSK5 (NP_006191.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QPYS PTNE FPKV ERFR YSRV EDPT DDYG TEDY AGPC DPEC SEVG CDGP GPDH CNDC LHYY YKLK NNTR ICVS SCPP GHYH ADKK RCRK CAPN CESC FGSH GDQC MSCK YGYF LNEE TNSC VTHC PDGS YQDT KKNL CRKC SENC KTCT EFHN CTEC RDGL SLQG SRCS VSCE DGRY FNGQ DCQP CHRF CATC AGAG ADGC INCT EGYF MEDG RCVQ SCSI SYYF DHSS ENGY KSCK KCDI SCLT CNGP GFKN CTSC PSGY LLDL GMCQ MGAI CKDA TEES WAEG GFCM LVKK NNLC QRKV LQQL CCKT CTFQ G |
| Gene ID: | 5125 |
| Uniprot: | Q92824 |
| Cellular Location: | Endomembrane system, Secreted, Single-pass type I membrane protein |
| Calculated MW: | 101kDa/206kDa |
| Observed MW: | 102kDa |
| Synonyms: | PCSK5, PC5, PC6, PC6A, SPC6 |
| Background: | This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). |
| UniProt Protein Function: | PCSK5: Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2 and CALD1. Belongs to the peptidase S8 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; EC 3.4.21.-; Protease Chromosomal Location of Human Ortholog: 9q21.3 Cellular Component: Golgi apparatus; extracellular space; Golgi lumen; integral to membrane; secretory granule Molecular Function:peptidase activity; serine-type endopeptidase activity; peptide binding Biological Process: signal peptide processing; nerve growth factor receptor signaling pathway; heart development; respiratory tube development; cytokine biosynthetic process; embryonic skeletal development; peptide hormone processing; viral infectious cycle; proteolysis; limb morphogenesis; peptide biosynthetic process; anterior/posterior pattern formation; nerve growth factor processing; cell-cell signaling; renin secretion into blood stream; protein processing; kidney development; embryonic gut development; embryo implantation |
| NCBI Summary: | This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, May 2014] |
| UniProt Code: | Q92824 |
| NCBI GenInfo Identifier: | 357529585 |
| NCBI Gene ID: | 5125 |
| NCBI Accession: | Q92824.4 |
| UniProt Secondary Accession: | Q92824,Q13527, Q96EP4, F5H2G7, |
| UniProt Related Accession: | Q92824 |
| Molecular Weight: | 101,649 Da |
| NCBI Full Name: | Proprotein convertase subtilisin/kexin type 5 |
| NCBI Synonym Full Names: | proprotein convertase subtilisin/kexin type 5 |
| NCBI Official Symbol: | PCSK5 |
| NCBI Official Synonym Symbols: | PC5; PC6; PC6A; SPC6 |
| NCBI Protein Information: | proprotein convertase subtilisin/kexin type 5; subtilase; protease PC6; prohormone convertase 5; proprotein convertase 6; subtilisin/kexin-like protease PC5 |
| UniProt Protein Name: | Proprotein convertase subtilisin/kexin type 5 |
| UniProt Synonym Protein Names: | Proprotein convertase 5; PC5; Proprotein convertase 6; PC6; hPC6; Subtilisin/kexin-like protease PC5 |
| Protein Family: | Proprotein convertase subtilisin/kexin |
| UniProt Gene Name: | PCSK5 |
| UniProt Entry Name: | PCSK5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PCSK5 antibody (CAB5450) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
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