Anti-PCNT Antibody (CAB20161)

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SKU:
CAB20161
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
KEN
PCN
MOPD2
PCNT2
PCNTB
PCTN2
SCKL4
Frequently bought together:

Description

Product Name:PCNT Rabbit pAb
Product Code:CAB20161
Size:50uL, 100uL
Synonyms:KEN, PCN, MOPD2, PCNT2, PCNTB, PCTN2, SCKL4
Applications:WB, IF
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human PCNT.
Applications:WB, IF
Recommended Dilutions:WB 1:1000 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Rat
Positive Samples:SH-SY5Y, Rat heart
Immunogen:Recombinant protein of human PCNT.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5116
Uniprot:O95613
Calculated MW:378kDa
Observed MW:251KDa/378KDa
UniProt Protein Function:PCNT: Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. Defects in PCNT are the cause of microcephalic osteodysplastic primordial dwarfism type 2 (MOPD2); also known as osteodysplastic primordial dwarfism type 2. Adults with this rare inherited condition have an average height of 100 centimeters and a brain size comparable to that of a 3-month-old baby, but are of near-normal intelligence. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Cell cycle regulationChromosomal Location of Human Ortholog: 21q22.3Cellular Component: centriole; microtubule; centrosome; pericentriolar material; intercellular bridge; membrane; cytoplasm; cytosolMolecular Function: calmodulin binding; protein bindingBiological Process: in utero embryonic development; multicellular organism growth; organelle organization and biogenesis; olfactory bulb development; neuron migration; microtubule cytoskeleton organization and biogenesis; spindle organization and biogenesis; limb morphogenesis; cerebellar cortex morphogenesis; brain morphogenesis; cilium biogenesis; mitotic cell cycle; G2/M transition of mitotic cell cycle; negative regulation of apoptosisDisease: Microcephalic Osteodysplastic Primordial Dwarfism, Type Ii
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. [provided by RefSeq, Jul 2008]
UniProt Code:O95613
NCBI GenInfo Identifier:81295809
NCBI Gene ID:5116
NCBI Accession:NP_006022.3
UniProt Secondary Accession:O95613,O43152, Q7Z7C9
UniProt Related Accession:O95613
Molecular Weight:
NCBI Full Name:pericentrin
NCBI Synonym Full Names:pericentrin
NCBI Official Symbol:PCNT  
NCBI Official Synonym Symbols:KEN; PCN; MOPD2; PCNT2; PCNTB; PCTN2; SCKL4  
NCBI Protein Information:pericentrin; kendrin; pericentrin-2; pericentrin-B; pericentrin-380
UniProt Protein Name:Pericentrin
UniProt Synonym Protein Names:Kendrin; Pericentrin-B
Protein Family:Pericentrin
UniProt Gene Name:PCNT  
UniProt Entry Name:PCNT_HUMAN

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