Anti-PCM1 Antibody (CAB16637)
- SKU:
- CAB16637
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-PCM1 Antibody |
| Antibody SKU: | CAB16637 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PCM1 (NP_006188.3). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | Raji, U-87MG |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PCM1 (NP_006188.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MATG GGPF EDGM NDQD LPNW SNEN VDDR LNNM DWGA QQKK ANRS SEKN KKKF GVES DKRV TNDI SPES SPGV GRRR TKTP HTFP HSRY MSQM SVPE QAEL EKLK QRIN FSDL DQRS IGSD SQGR ATAA NNKR QLSE NRKP FNFL PMQI NTNK SKDA STSP PNRE TIGS AQCK ELFA SALS NDLL QNCQ VSEE DGRG EPAM ESSQ IVSR LVQI RDYI TKAS SMRE DLVE KNER SANV ERLT HLID HLKE QEKS YMKF LKKI |
| Gene ID: | 5108 |
| Uniprot: | Q15154 |
| Cellular Location: | Cytoplasm, Cytoplasmic granule, centriolar satellite, centrosome, cilium basal body, cytoskeleton, microtubule organizing center |
| Calculated MW: | 59kDa/222kDa/228kDa |
| Observed MW: | 280kDa |
| Synonyms: | PCM1, PTC4, RET/PCM-1 |
| Background: | The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Code: | Q15154 |
| NCBI GenInfo Identifier: | 134142826 |
| NCBI Gene ID: | 5108 |
| NCBI Accession: | NP_006188.3 |
| UniProt Secondary Accession: | Q15154,Q58F13, Q6P1K7, Q8NB85, Q9BWC1, Q9H4A2, |
| UniProt Related Accession: | Q15154 |
| Molecular Weight: | 59,199 Da |
| NCBI Full Name: | pericentriolar material 1 protein |
| NCBI Synonym Full Names: | pericentriolar material 1 |
| NCBI Official Symbol: | PCM1 |
| NCBI Official Synonym Symbols: | PTC4 |
| NCBI Protein Information: | pericentriolar material 1 protein; PCM-1; hPCM-1; pericentriolar material 1, PCM1 |
| UniProt Protein Name: | Pericentriolar material 1 protein |
| Protein Family: | Pericentriolar material 1 protein |
| UniProt Gene Name: | PCM1 |
| UniProt Entry Name: | PCM1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PCM1 antibody (CAB16637) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 120s. |
 | Immunofluorescence analysis of HeLa cells using PCM1 antibody (CAB16637). Blue: DAPI for nuclear staining. |
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