Anti-PCDHB16 Antibody (CAB15493)
- SKU:
- CAB15493
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-PCDHB16 Antibody |
| Antibody SKU: | CAB15493 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-90 of human PCDHB16 (NP_066008.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-90 of human PCDHB16 (NP_066008.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ELGS YSVV EETE RGSF VANL GKDL GLGL TEMS TRKA RIIS QGNK QHLQ LKAQ TGDL LINE KL |
| Gene ID: | 57717 |
| Uniprot: | Q9NRJ7 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 84kDa |
| Observed MW: | 85kDa |
| Synonyms: | PCDHB16, ME1, PCDH-BETA16, PCDH3X, PCDHB8a |
| Background: | This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. |
| UniProt Protein Function: | PCDHB16: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 5q31 Cellular Component: integral to membrane; plasma membrane Molecular Function:calcium ion binding Biological Process: synaptic transmission; synaptogenesis; calcium-dependent cell-cell adhesion; homophilic cell adhesion |
| NCBI Summary: | This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NRJ7 |
| NCBI GenInfo Identifier: | 605052038 |
| NCBI Gene ID: | 57717 |
| NCBI Accession: | NP_066008.2 |
| UniProt Secondary Accession: | Q9NRJ7,Q8IYD5, Q96SE9, Q9HCF1, B3KPK5, |
| UniProt Related Accession: | Q9NRJ7 |
| Molecular Weight: | 84,983 Da |
| NCBI Full Name: | protocadherin beta-16 |
| NCBI Synonym Full Names: | protocadherin beta 16 |
| NCBI Official Symbol: | PCDHB16 |
| NCBI Official Synonym Symbols: | ME1; PCDH3X; PCDHB8a; PCDH-BETA16 |
| NCBI Protein Information: | protocadherin beta-16; cadherin ME1; protocadherin beta 8a; protocadherin-3x |
| UniProt Protein Name: | Protocadherin beta-16 |
| UniProt Synonym Protein Names: | Protocadherin-3X |
| Protein Family: | Protocadherin |
| UniProt Gene Name: | PCDHB16 |
| UniProt Entry Name: | PCDBG_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PCDHB16 antibody (CAB15493) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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