Anti-PCDH19 Antibody (CAB10067)

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SKU:
CAB10067
Product type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-PCDH19 Antibody
Antibody SKU:CAB10067
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 568-678 of human PCDH19 (NP_001171809.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 568-678 of human PCDH19 (NP_001171809.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LING TAEV YIPR NSGI GYLV TVVK AEDY DEGE NGRV TYDM TEGD RGFF EIDQ VNGE VRTT RTFG ESSK SSYE LIVV AHDH GKTS LSAS ALVL IYLS PALD AQES MGSV NLS
Gene ID:57526
Uniprot:Q8TAB3
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:121kDa/126kDa
Observed MW:170kDa
Synonyms:PCDH19, EFMR, EIEE9
Background:The protein encoded by this gene is a member of the delta-2 protocadherin subclass of the cadherin superfamily. The encoded protein is thought to be a calcium-dependent cell-adhesion protein that is primarily expressed in the brain. Defects in this gene are a cause of epilepsy female-restricted with mental retardation (EFMR). Three transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:PCDH19: Potential calcium-dependent cell-adhesion protein. Defects in PCDH19 are the cause of epileptic encephalopathy early infantile type 9 (EIEE9); also known as epilepsy female-restricted with mental retardation. A condition characterized by seizure with onset in infancy or early childhood, cognitive impairment, and delayed development of variable severity in some patients. Additional features include autistic signs and psychosis. The disorder is sex-limited, with the phenotype being restricted to females. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq22.1

Cellular Component: integral to membrane; plasma membrane

Molecular Function:calcium ion binding

Biological Process: homophilic cell adhesion

Disease: Epileptic Encephalopathy, Early Infantile, 9

NCBI Summary:The protein encoded by this gene is a member of the delta-2 protocadherin subclass of the cadherin superfamily. The encoded protein is thought to be a calcium-dependent cell-adhesion protein that is primarily expressed in the brain. Defects in this gene are a cause of epilepsy female-restricted with mental retardation (EFMR). Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
UniProt Code:Q8TAB3
NCBI GenInfo Identifier:157426847
NCBI Gene ID:57526
NCBI Accession:NP_001098713.1
UniProt Secondary Accession:Q8TAB3,Q5JTG1, Q5JTG2, Q68DT7, Q9P2N3, B0LDS4, E9PAM6
UniProt Related Accession:Q8TAB3
Molecular Weight:121,014 Da
NCBI Full Name:protocadherin-19 isoform a
NCBI Synonym Full Names:protocadherin 19
NCBI Official Symbol:PCDH19  
NCBI Official Synonym Symbols:EFMR; EIEE9  
NCBI Protein Information:protocadherin-19
UniProt Protein Name:Protocadherin-19
Protein Family:Protocadherin
UniProt Gene Name:PCDH19  
UniProt Entry Name:PCD19_HUMAN
Anti-PCDH19 Antibody (CAB10067)Western blot analysis of extracts of 293T cells, using PCDH19 antibody (CAB10067) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

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