Anti-PCDH1 Antibody (CAB10234)
- SKU:
- CAB10234
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-PCDH1 Antibody |
| Antibody SKU: | CAB10234 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-220 of human PCDH1 (NP_002578.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | U-87MG, LO2, HeLa, SW480, BT-474 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-220 of human PCDH1 (NP_002578.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VVYK VPEE QPPN TLIG SLAA DYGF PDVG HLYK LEVG APYL RVDG KTGD IFTT ETSI DREG LREC QNQL PGDP CILE FEVS ITDL VQNG SPRL LEGQ IEVQ DIND NTPN FASP VITL AIPE NTNI GSLF PIPL ASDR DAGP NGVA SYEL QAGP EAQE LFGL Q |
| Gene ID: | 5097 |
| Uniprot: | Q08174 |
| Cellular Location: | Cell junction, Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 114kDa/133kDa |
| Observed MW: | 115kDa |
| Synonyms: | PCDH1, PC42, PCDH42 |
| Background: | This gene belongs to the protocadherin subfamily within the cadherin superfamily. The encoded protein is a membrane protein found at cell-cell boundaries. It is involved in neural cell adhesion, suggesting a possible role in neuronal development. The protein includes an extracelllular region, containing 7 cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. Cells expressing the protein showed cell aggregation activity. Alternative splicing occurs in this gene. |
| UniProt Protein Function: | PCDH1: a protocadherin protein within the cadherin superfamily. A membrane protein found at cell-cell boundaries. Involved in neural cell adhesion, suggesting a possible role in neuronal development. Contains an extracelllular region with 7 cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. Cells expressing the protein showed cell aggregation activity. Alternative splicing occurs in this gene. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 5q31.3 Cellular Component: integral to plasma membrane; intercellular junction; plasma membrane Biological Process: cell-cell signaling; nervous system development |
| NCBI Summary: | This gene belongs to the protocadherin subfamily within the cadherin superfamily. The encoded protein is a membrane protein found at cell-cell boundaries. It is involved in neural cell adhesion, suggesting a possible role in neuronal development. The protein includes an extracelllular region, containing 7 cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. Cells expressing the protein showed cell aggregation activity. Alternative splicing occurs in this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q08174 |
| NCBI GenInfo Identifier: | 215273864 |
| NCBI Gene ID: | 5097 |
| NCBI Accession: | Q08174.2 |
| UniProt Secondary Accession: | Q08174,Q8IUP2, |
| UniProt Related Accession: | Q08174 |
| Molecular Weight: | 133,722 Da |
| NCBI Full Name: | Protocadherin-1 |
| NCBI Synonym Full Names: | protocadherin 1 |
| NCBI Official Symbol: | PCDH1 |
| NCBI Official Synonym Symbols: | PC42; PCDH42 |
| NCBI Protein Information: | protocadherin-1 |
| UniProt Protein Name: | Protocadherin-1 |
| UniProt Synonym Protein Names: | Cadherin-like protein 1; Protocadherin-42; PC42 |
| Protein Family: | Protocadherin |
| UniProt Gene Name: | PCDH1 |
| UniProt Entry Name: | PCDH1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PCDH1 antibody (CAB10234) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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