Anti-PARS2 Antibody (CAB16512)

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SKU:
CAB16512
Product type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
Frequently bought together:

Description

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Antibody Name:Anti-PARS2 Antibody
Antibody SKU:CAB16512
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 30-220 of human PARS2 (NP_689481.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:Jurkat, U-251MG
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 30-220 of human PARS2 (NP_689481.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:HHCA PRRG RRLL LSRV FQPQ NLRE DRVL SLQD KSDD LTCK SQRL MLQV GLIY PASP GCYH LLPY TVRA MEKL VRVI DQEM QAIG GQKV NMPS LSPA ELWQ ATNR WDLM GKEL LRLR DRHG KEYC LGPT HEEA ITAL IASQ KKLS YKQL PFLL YQVT RKFR DEPR PRFG LLRG REFY MKDM YTFD SSPE AAQ
Gene ID:25973
Uniprot:Q7L3T8
Cellular Location:Mitochondrion matrix
Calculated MW:53kDa
Observed MW:51kDa
Synonyms:PARS2, MT-PRORS, proRS
Background:This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of proline to tRNA molecules. Mutations have been found in this gene in some patients with Alpers syndrome.
UniProt Protein Function:PARS2: Belongs to the class-II aminoacyl-tRNA synthetase family.
UniProt Protein Details:

Protein type:Ligase; Mitochondrial; EC 6.1.1.15

Chromosomal Location of Human Ortholog: 1p32.2

Cellular Component: mitochondrion

Molecular Function:proline-tRNA ligase activity; RNA binding

Biological Process: prolyl-tRNA aminoacylation

NCBI Summary:This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of proline to tRNA molecules. Mutations have been found in this gene in some patients with Alpers syndrome. [provided by RefSeq, Mar 2015]
UniProt Code:Q7L3T8
NCBI GenInfo Identifier:73919761
NCBI Gene ID:25973
NCBI Accession:Q7L3T8.1
UniProt Secondary Accession:Q7L3T8,Q9H6S5, Q9UFT1, A8K0W4,
UniProt Related Accession:Q7L3T8
Molecular Weight:53,263 Da
NCBI Full Name:Probable proline--tRNA ligase, mitochondrial
NCBI Synonym Full Names:prolyl-tRNA synthetase 2, mitochondrial (putative)
NCBI Official Symbol:PARS2  
NCBI Official Synonym Symbols:proRS; MT-PRORS  
NCBI Protein Information:probable proline--tRNA ligase, mitochondrial
UniProt Protein Name:Probable proline--tRNA ligase, mitochondrial
UniProt Synonym Protein Names:Prolyl-tRNA synthetase; ProRS
UniProt Gene Name:PARS2  
UniProt Entry Name:SYPM_HUMAN
Anti-PARS2 Antibody (CAB16512)Western blot analysis of extracts of various cell lines, using PARS2 antibody (CAB16512) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.

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