Anti-PARP4 Antibody (CAB16749)
- SKU:
- CAB16749
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-PARP4 Antibody |
| Antibody SKU: | CAB16749 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PARP4 (NP_006428.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PARP4 (NP_006428.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MVMG IFAN CIFC LKVK YLPQ QQKK KLQT DIKE NGGK FSFS LNPQ CTHI ILDN ADVL SQYQ LNSI QKNH VHIA NPDF IWKS IREK RLLD VKNY DPYK PLDI TPPP DQKA SSSE VKTE GLCP DSAT EEED TVEL TEFG MQNV EIPH LPQD FEVA KYNT LEKV GMEG GQEA VVVE LQCS RDSR DCPF LISS HFLL DDGM ETRR QFAI KKTS EDAS EYFE NYIE ELKK QGFL LREH FTPE ATQL ASEQ LQAL LLEE VMNS STLS QEVS DLVE MIWA EALG HLEH MLLK PVNR ISLN DVSK AEGI |
| Gene ID: | 143 |
| Uniprot: | Q9UKK3 |
| Cellular Location: | Cytoplasm, Nucleus, cytoskeleton, spindle |
| Calculated MW: | 192kDa |
| Observed MW: | 250kDa |
| Synonyms: | PARP4, ADPRTL1, ARTD4, PARP-4, PARPL, PH5P, VAULT3, VPARP, VWA5C, p193 |
| Background: | This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. |
| UniProt Protein Function: | PARP4: Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). Binds to MVP. Associates with TEP1. |
| UniProt Protein Details: | Protein type:Transferase; EC 2.4.2.30 Chromosomal Location of Human Ortholog: 13q11 Cellular Component: membrane; spindle microtubule; cytoplasm; ribonucleoprotein complex; nucleus Molecular Function:protein binding; enzyme binding; DNA binding; NAD+ ADP-ribosyltransferase activity Biological Process: response to drug; cell death; protein amino acid ADP-ribosylation; transport; protein modification process; DNA repair; inflammatory response; response to DNA damage stimulus |
| NCBI Summary: | This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UKK3 |
| NCBI GenInfo Identifier: | 112789550 |
| NCBI Gene ID: | 143 |
| NCBI Accession: | NP_006428.2 |
| UniProt Secondary Accession: | Q9UKK3,O75903, Q14682, Q5QNZ9, Q9H1M6, |
| UniProt Related Accession: | Q9UKK3 |
| Molecular Weight: | 192,595 Da |
| NCBI Full Name: | poly |
| NCBI Synonym Full Names: | poly (ADP-ribose) polymerase family, member 4 |
| NCBI Official Symbol: | PARP4 |
| NCBI Official Synonym Symbols: | PH5P; p193; ARTD4; PARPL; VPARP; VWA5C; PARP-4; VAULT3; ADPRTL1 |
| NCBI Protein Information: | poly [ADP-ribose] polymerase 4; poly [ADP-ribose] polymerase 4; 193 kDa vault protein; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 1; ADP-ribosyltransferase diphtheria toxin-like 4; H5 proline-rich; I-alpha-I-related; PARP-related; PARP-related/IalphaI-related H5/proline-rich; poly(ADP-ribose) synthetase; poly(ADP-ribosyl)transferase-like 1; vault poly(ADP-ribose) polymerase; vault protein, 193-kDa; von Willebrand factor A domain containing 5C |
| UniProt Protein Name: | Poly [ADP-ribose] polymerase 4 |
| UniProt Synonym Protein Names: | 193 kDa vault protein; ADP-ribosyltransferase diphtheria toxin-like 4; ARTD4; PARP-related/IalphaI-related H5/proline-rich; PH5P; Vault poly(ADP-ribose) polymerase; VPARP |
| Protein Family: | Poly [ADP-ribose] polymerase |
| UniProt Gene Name: | PARP4 |
| UniProt Entry Name: | PARP4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PARP4 Rabbit pAb (CAB16749) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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