Anti-PARP2 Antibody (CAB16475)

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SKU:
CAB16475
Product type:
Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
Frequently bought together:

Description

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Antibody Name:Anti-PARP2 Antibody
Antibody SKU:CAB16475
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 450-550 of human PARP2 (NP_001036083.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 450-550 of human PARP2 (NP_001036083.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FADM SSKS ANYC FASR LKNT GLLL LSEV ALGQ CNEL LEAN PKAE GLLQ GKHS TKGL GKMA PSSA HFVT LNGS TVPL GPAS DTGI LNPD GYTL NYNE YIVY N
Gene ID:10038
Uniprot:Q9UGN5
Cellular Location:Nucleus
Calculated MW:64kDa/66kDa
Observed MW:Refer to figures
Synonyms:PARP2, ADPRT2, ADPRTL2, ADPRTL3, ARTD2, PARP-2, pADPRT-2
Background:This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found.
UniProt Protein Function:Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism (PubMed:10364231, PubMed:28190768). This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231). Mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768).
NCBI Summary:This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UGN5
NCBI GenInfo Identifier:110825961
NCBI Gene ID:10038
NCBI Accession:NP_005475
UniProt Secondary Accession:Q9UGN5,Q8TEU4, Q9NUV2, Q9UMR4, Q9Y6C8,
UniProt Related Accession:Q9UGN5
Molecular Weight:42.5 kDa (376aa)
NCBI Full Name:poly
NCBI Synonym Full Names:poly(ADP-ribose) polymerase 2
NCBI Official Symbol:PARP2  
NCBI Official Synonym Symbols:ARTD2; ADPRT2; PARP-2; ADPRTL2; ADPRTL3; pADPRT-2  
NCBI Protein Information:poly [ADP-ribose] polymerase 2
UniProt Protein Name:Poly [ADP-ribose] polymerase 2
UniProt Synonym Protein Names:ADP-ribosyltransferase diphtheria toxin-like 2; ARTD2; NAD(+) ADP-ribosyltransferase 2; ADPRT-2; Poly[ADP-ribose] synthase 2; pADPRT-2
Protein Family:Poly [ADP-ribose] polymerase
UniProt Gene Name:PARP2  

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