Anti-Parathyroid Hormone (PTH) Antibody (CAB9704)

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SKU:
CAB9704
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
PTH1
Frequently bought together:

Description

Product Name:Parathyroid Hormone (PTH) Rabbit mAb
Product Code:CAB9704
Size:20uL, 50uL, 100uL
Synonyms:PTH1
Applications:WB, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Parathyroid Hormone (PTH) (PTH)
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse thymus, Rat thymus, Jurkat
Immunogen:A synthesized peptide derived from human Parathyroid Hormone (PTH) (PTH)
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5741
Uniprot:P01270
Cellular Location:Secreted
Calculated MW:36kDa
Observed MW:13kDa
UniProt Protein Function:PTH: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism. Belongs to the parathyroid hormone family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted; Hormone; Apoptosis

Chromosomal Location of Human Ortholog: 11p15.3-p15.1

Cellular Component: extracellular space; extracellular region

Molecular Function:RNA polymerase II transcription factor activity, enhancer binding; type 1 parathyroid hormone receptor binding; parathyroid hormone receptor binding; peptide hormone receptor binding; hormone activity

Biological Process: response to drug; transcription from RNA polymerase II promoter; positive regulation of signal transduction; induction of apoptosis by hormones; positive regulation of glycogen biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of bone mineralization; G-protein signaling, adenylate cyclase activating pathway; Rho protein signal transduction; cellular calcium ion homeostasis; positive regulation of glucose import; G-protein coupled receptor protein signaling pathway; cAMP metabolic process; response to vitamin D; response to cadmium ion; response to ethanol; cell-cell signaling; regulation of gene expression; positive regulation of cAMP biosynthetic process; response to lead ion; positive regulation of transcription from RNA polymerase II promoter; skeletal development; bone resorption

Disease: Hypoparathyroidism, Familial Isolated

NCBI Summary:The protein encoded by this gene is a hormone secreted by parathyroid cells. This hormone elevates blood Ca2+ level by dissolving the salts in bone and preventing their renal excretion. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH). [provided by RefSeq, Jul 2008]
UniProt Code:P01270
NCBI GenInfo Identifier:131547
NCBI Gene ID:5741
NCBI Accession:P01270.1
UniProt Secondary Accession:P01270,Q4VB48, Q9UD38,
UniProt Related Accession:P01270
Molecular Weight:12,861 Da
NCBI Full Name:Parathyroid hormone
NCBI Synonym Full Names:parathyroid hormone
NCBI Official Symbol:PTH  
NCBI Official Synonym Symbols:PTH1  
NCBI Protein Information:parathyroid hormone; parathyrin; prepro-PTH; parathormone; parathyroid hormone 1; preproparathyroid hormone
UniProt Protein Name:Parathyroid hormone
UniProt Synonym Protein Names:Parathormone; Parathyrin
Protein Family:Parathyroid hormone
UniProt Gene Name:PTH  
UniProt Entry Name:PTHY_HUMAN

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