Anti-PAR4 Antibody (CAB4983)

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SKU:
CAB4983
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
PAR4
Par-4
Frequently bought together:

Description

Product Name:PAR4 Rabbit mAb
Product Code:CAB4983
Size:20uL, 50uL, 100uL
Synonyms:PAR4, Par-4
Applications:WB, IHC, IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human PAR4
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:HeLa, SW620, 293T, Mouse lung
Immunogen:A synthesized peptide derived from human PAR4
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5074
Uniprot:Q96IZ0
Cellular Location:Cytoplasm, Nucleus
Calculated MW:40kDa
Observed MW:41kDa
UniProt Protein Function:PAR-4: a proapoptotic protein that drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression. Capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappaB transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
UniProt Protein Details:

Protein type:Apoptosis

Chromosomal Location of Human Ortholog: 12q21

Cellular Component: cytoplasm; plasma membrane; actin filament; nucleus; actin cytoskeleton

Molecular Function:protein binding; leucine zipper domain binding; enzyme binding; actin binding; transcription corepressor activity

Biological Process: negative regulation of cell proliferation; actin filament bundle formation; negative regulation of T cell proliferation; interleukin-2 biosynthetic process; transcription, DNA-dependent; apoptosis; positive regulation of apoptosis; negative regulation of T cell receptor signaling pathway; negative regulation of B cell proliferation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of amyloid precursor protein biosynthetic process

NCBI Summary:The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells. [provided by RefSeq, Jul 2008]
UniProt Code:Q96IZ0
NCBI GenInfo Identifier:66773935
NCBI Gene ID:5074
NCBI Accession:Q96IZ0.1
UniProt Secondary Accession:Q96IZ0,O75796, Q6FHY9, Q8N700,
UniProt Related Accession:Q96IZ0
Molecular Weight:340
NCBI Full Name:PRKC apoptosis WT1 regulator protein
NCBI Synonym Full Names:PRKC, apoptosis, WT1, regulator
NCBI Official Symbol:PAWR  
NCBI Official Synonym Symbols:PAR4; Par-4  
NCBI Protein Information:PRKC apoptosis WT1 regulator protein; WT1-interacting protein; prostate apoptosis response-4; transcriptional repressor PAR4; prostate apoptosis response 4 protein; prostate apoptosis response protein 4; prostate apoptosis response protein PAR-4
UniProt Protein Name:PRKC apoptosis WT1 regulator protein
UniProt Synonym Protein Names:Prostate apoptosis response 4 protein; Par-4
Protein Family:PRKC apoptosis WT1 regulator protein
UniProt Gene Name:PAWR  
UniProt Entry Name:PAWR_HUMAN

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