| UniProt Protein Function: | Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:9576487, PubMed:9668121, PubMed:9648242, PubMed:14747722). Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells (PubMed:9576487). |
| NCBI Summary: | Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM, Mar 2008] |
| UniProt Code: | O43252 |
| NCBI GenInfo Identifier: | 46094058 |
| NCBI Gene ID: | 9061 |
| NCBI Accession: | NP_005434 |
| UniProt Secondary Accession: | O43252,O43841, O75332, Q6IAX6, Q96FB1, Q96TF4, Q9P1P9 Q9UE98, |
| UniProt Related Accession: | O43252 |
| Molecular Weight: | 70.9 kDa (626aa) |
| NCBI Full Name: | bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 |
| NCBI Synonym Full Names: | 3'-phosphoadenosine 5'-phosphosulfate synthase 1 |
| NCBI Official Symbol: | PAPSS1 |
| NCBI Official Synonym Symbols: | SK1; PAPSS; ATPSK1 |
| NCBI Protein Information: | bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 |
| UniProt Protein Name: | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 |
| UniProt Synonym Protein Names: | 3'-phosphoadenosine-5'-phosphosulfate synthase; APS kinase; Adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenylylsulfate 3'-phosphotransferase |
| Protein Family: | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase |
| UniProt Gene Name: | PAPSS1 |
