Anti-Pannexin 1 Antibody (CAB5167)
- SKU:
- CAB5167
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-Pannexin 1 Antibody |
| Antibody SKU: | CAB5167 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Pannexin 1 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | C2C12, K-562, U-87MG, Mouse brain, Rat brain |
| Immunogen: | A synthesized peptide derived from human Pannexin 1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 24145 |
| Uniprot: | Q96RD7 |
| Cellular Location: | |
| Calculated MW: | 48kDa |
| Observed MW: | 50KDa |
| Synonyms: | MRS1, PX1, UNQ2529 |
| Background: | The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | PANX1: Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis. Belongs to the pannexin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 11q21 Cellular Component: endoplasmic reticulum membrane; protein complex; membrane; endoplasmic reticulum; integral to membrane; plasma membrane; gap junction Molecular Function:actin filament binding; protease binding; leak channel activity; protein heterodimerization activity; gap junction hemi-channel activity; calcium channel activity; receptor binding Biological Process: positive regulation of interleukin-1 alpha secretion; synaptic transmission; calcium ion transport; innate immune response; positive regulation of interleukin-1 beta secretion; cation transport; response to ATP |
| NCBI Summary: | The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96RD7 |
| NCBI GenInfo Identifier: | 317373551 |
| NCBI Gene ID: | 24145 |
| NCBI Accession: | Q96RD7.4 |
| UniProt Secondary Accession: | Q96RD7,O75968, Q543A0, Q6UW26, Q96AM9, Q96L77, Q96RS5 |
| UniProt Related Accession: | Q96RD7 |
| Molecular Weight: | 426 |
| NCBI Full Name: | Pannexin-1 |
| NCBI Synonym Full Names: | pannexin 1 |
| NCBI Official Symbol: | PANX1 |
| NCBI Official Synonym Symbols: | PX1; MRS1; UNQ2529 |
| NCBI Protein Information: | pannexin-1; innexin |
| UniProt Protein Name: | Pannexin-1 |
| Protein Family: | Pannexin |
| UniProt Gene Name: | PANX1 |
| UniProt Entry Name: | PANX1_HUMAN |
 | Western blot - Pannexin 1 Rabbit mAb (CAB5167) |
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