Anti-PAK5 Antibody (CAB15872)
- SKU:
- CAB15872
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-PAK5 Antibody |
| Antibody SKU: | CAB15872 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 600-700 of human PAK7 (NP_065074.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | U-87MG |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 600-700 of human PAK7 (NP_065074.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RKSL VGTP YWMA PEVI SRLP YGTE VDIW SLGI MVIE MIDG EPPY FNEP PLQA MRRI RDSL PPRV KDLH KVSS VLRG FLDL MLVR EPSQ RATA QELL GHPF L |
| Gene ID: | 57144 |
| Uniprot: | Q9P286 |
| Cellular Location: | Cytoplasm, Mitochondrion, Nucleus |
| Calculated MW: | 80kDa |
| Observed MW: | 81kDa |
| Synonyms: | PAK5, PAK7 |
| Background: | The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. |
| UniProt Protein Function: | PAK5: a protein kinase of the STE20 family. Predominantly expressed in brain. Capable of promoting neurite outgrowth, and thus may play a role in neurite development. Associated with microtubule networks and induces microtubule stabilization. Its subcellular localization is tightly regulated during cell cycle progression. |
| UniProt Protein Details: | Protein type:EC 2.7.11.1; Protein kinase, STE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; PAKB subfamily Chromosomal Location of Human Ortholog: 20p12 Cellular Component: mitochondrion; cytoplasm; nucleus Molecular Function:ATP binding; receptor signaling protein serine/threonine kinase activity Biological Process: cell proliferation; cell migration; apoptosis; cytoskeleton organization and biogenesis; locomotory behavior; learning; mitotic cell cycle; cell growth; signal transduction; protein amino acid phosphorylation; memory |
| NCBI Summary: | The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9P286 |
| NCBI GenInfo Identifier: | 12585290 |
| NCBI Gene ID: | 57144 |
| NCBI Accession: | Q9P286.1 |
| UniProt Secondary Accession: | Q9P286,Q5W115, Q9BX09, Q9ULF6, A8K5T6, D3DW14, |
| UniProt Related Accession: | Q9P286 |
| Molecular Weight: | 719 |
| NCBI Full Name: | Serine/threonine-protein kinase PAK 7 |
| NCBI Synonym Full Names: | p21 protein (Cdc42/Rac)-activated kinase 7 |
| NCBI Official Symbol: | PAK7 |
| NCBI Official Synonym Symbols: | PAK5 |
| NCBI Protein Information: | serine/threonine-protein kinase PAK 7; PAK-5; PAK-7; protein kinase PAK5; p21-activated kinase 5; p21-activated kinase 7; p21CDKN1A-activated kinase 7; serine/threonine-protein kinase PAK7 |
| UniProt Protein Name: | Serine/threonine-protein kinase PAK 7 |
| UniProt Synonym Protein Names: | p21-activated kinase 5; PAK-5; p21-activated kinase 7; PAK-7 |
| UniProt Gene Name: | PAK7 |
| UniProt Entry Name: | PAK7_HUMAN |
 | Western blot analysis of extracts of U-87MG cells, using PAK7 antibody (CAB15872) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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