Anti-p53 DINP1 Antibody (CAB5952)

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SKU:
CAB5952
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
SIP
TP53DINP1
TP53INP1A
TP53INP1B
Teap
p53DINP1
Frequently bought together:

Description

Product Name:p53 DINP1 Rabbit mAb
Product Code:CAB5952
Size:20uL, 50uL, 100uL
Synonyms:SIP, TP53DINP1, TP53INP1A, TP53INP1B, Teap, p53DINP1
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human p53 DINP1
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, A-549, BxPC-3, RAW264.7, C6, Mouse lung, Mouse liver, Rat lung
Immunogen:A synthesized peptide derived from human p53 DINP1
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:94241
Uniprot:Q96A56
Calculated MW:32kDa
Observed MW:27KDa
UniProt Protein Function:TP53INP1: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Apoptosis; Tumor suppressor; Cell cycle regulation

Chromosomal Location of Human Ortholog: 8q22

Cellular Component: PML body; autophagic vacuole; cytoplasmic vesicle; nucleus; cytosol

Molecular Function:antioxidant activity; protein binding

Biological Process: negative regulation of cell proliferation; transcription, DNA-dependent; response to heat; apoptosis; positive regulation of transcription, DNA-dependent; autophagic cell death; response to stress; cell cycle arrest; negative regulation of cell migration; positive regulation of autophagy; autophagic vacuole formation

UniProt Code:Q96A56
NCBI GenInfo Identifier:209180469
NCBI Gene ID:94241
NCBI Accession:NP_001129205.1
UniProt Secondary Accession:Q96A56,Q969R9, B2RCE5,
UniProt Related Accession:Q96A56
Molecular Weight:27,366 Da
NCBI Full Name:tumor protein p53-inducible nuclear protein 1 isoform b
NCBI Synonym Full Names:tumor protein p53 inducible nuclear protein 1
NCBI Official Symbol:TP53INP1  
NCBI Official Synonym Symbols:SIP; Teap; p53DINP1; TP53DINP1; TP53INP1A; TP53INP1B  
NCBI Protein Information:tumor protein p53-inducible nuclear protein 1; p53-inducible p53DINP1; stress-induced protein; p53-dependent damage-inducible nuclear protein 1
UniProt Protein Name:Tumor protein p53-inducible nuclear protein 1
UniProt Synonym Protein Names:Stress-induced protein; p53-dependent damage-inducible nuclear protein 1
Protein Family:Tumor protein p53-inducible nuclear protein
UniProt Gene Name:TP53INP1  
UniProt Entry Name:T53I1_HUMAN

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