Anti-P2RY4 Antibody (CAB3059)

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SKU:
CAB3059
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-P2RY4 Antibody
Antibody SKU:CAB3059
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 286-365 of human P2RY4 (NP_002556.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:BxPC-3, A-549, Mouse stomach, Mouse heart, Mouse lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 286-365 of human P2RY4 (NP_002556.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VVYK VTRP LASA NSCL DPVL YLLT GDKY RRQL RQLC GGGK PQPR TAAS SLAL VSLP EDSS CRWA ATPQ DSSC STPR ADRL
Gene ID:5030
Uniprot:P51582
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:40kDa
Observed MW:41kDa
Synonyms:P2RY4, NRU, P2P, P2Y4, UNR
Background:The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP.
UniProt Protein Function:P2RY4: Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: Xq13

Cellular Component: integral to plasma membrane; basolateral plasma membrane; apical plasma membrane; plasma membrane

Molecular Function:purinergic nucleotide receptor activity, G-protein coupled; UTP-activated nucleotide receptor activity; ATP binding; uridine nucleotide receptor activity

Biological Process: elevation of cytosolic calcium ion concentration; transepithelial chloride transport; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)

NCBI Summary:The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP. [provided by RefSeq, Jul 2008]
UniProt Code:P51582
NCBI GenInfo Identifier:1709524
NCBI Gene ID:5030
NCBI Accession:P51582.1
UniProt Secondary Accession:P51582,Q4VBB7, Q4VBB8, Q502W2, Q5JT22,
UniProt Related Accession:P51582
Molecular Weight:40,963 Da
NCBI Full Name:P2Y purinoceptor 4
NCBI Synonym Full Names:pyrimidinergic receptor P2Y, G-protein coupled, 4
NCBI Official Symbol:P2RY4  
NCBI Official Synonym Symbols:NRU; P2P; UNR; P2Y4  
NCBI Protein Information:P2Y purinoceptor 4; uridine nucleotide receptor
UniProt Protein Name:P2Y purinoceptor 4
UniProt Synonym Protein Names:P2P; Uridine nucleotide receptor; UNR
Protein Family:P2Y purinoceptor
UniProt Gene Name:P2RY4  
UniProt Entry Name:P2RY4_HUMAN
Anti-P2RY4 Antibody (CAB3059)Western blot analysis of extracts of various cell lines, using P2RY4 antibody (CAB3059) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.

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