Anti-P2RY12 Antibody (CAB1710)

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SKU:
CAB1710
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cardiovascular
Frequently bought together:

Description

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Antibody Name:Anti-P2RY12 Antibody
Antibody SKU:CAB1710
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human P2RY12 (NP_795345.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:U-251MG, HepG2, PC-12, DU145, Mouse brain, Rat testis
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human P2RY12 (NP_795345.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:INFL IVIV CYTL ITKE LYRS YVRT RGVG KVPR KKVN VKVF IIIA VFFI CFVP FHFA RIPY TLSQ TRDV FDCT AENT LFYV KEST LWLT SLNA CLDP FIYF FLCK SFRN SLIS MLKC PNSA TSLS QDNR KKEQ DGGD PNEE TPM
Gene ID:64805
Uniprot:Q9H244
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:39kDa
Observed MW:50kDa
Synonyms:P2RY12, ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12, SP1999
Background:The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene.
UniProt Code:Q9H244
NCBI GenInfo Identifier:12232483
NCBI Gene ID:64805
NCBI Accession:NP_073625
UniProt Secondary Accession:Q9H244,Q546J7, D3DNJ5,
UniProt Related Accession:Q9H244
Molecular Weight:39,439 Da
NCBI Full Name:P2Y purinoceptor 12
NCBI Synonym Full Names:purinergic receptor P2Y, G-protein coupled, 12
NCBI Official Symbol:P2RY12  
NCBI Official Synonym Symbols:HORK3; P2Y12; ADPG-R; BDPLT8; SP1999; P2T(AC); P2Y(AC); P2Y(12)R; P2Y(ADP); P2Y(cyc)  
NCBI Protein Information:P2Y purinoceptor 12; ADP-glucose receptor; G-protein coupled receptor SP1999; Gi-coupled ADP receptor HORK3; P2Y12 platelet ADP receptor; purinergic receptor P2RY12; putative G-protein coupled receptor
UniProt Protein Name:P2Y purinoceptor 12
UniProt Synonym Protein Names:ADP-glucose receptor; ADPG-R; P2T(AC); P2Y(AC); P2Y(cyc); P2Y12 platelet ADP receptor; P2Y(ADP); SP1999
Protein Family:Proteinase-activated receptor
UniProt Gene Name:P2RY12  
UniProt Entry Name:P2Y12_HUMAN
Anti-P2RY12 Antibody (CAB1710)Western blot analysis of extracts of various cell lines, using P2RY12 antibody (CAB1710) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s.
Anti-P2RY12 Antibody (CAB1710)Immunofluorescence analysis of C6 cells using P2RY12 antibody (CAB1710) at dilution of 1:100. Blue: DAPI for nuclear staining.
Anti-P2RY12 Antibody (CAB1710)Immunofluorescence analysis of U-87MG cells using P2RY12 antibody (CAB1710) at dilution of 1:100. Blue: DAPI for nuclear staining.
Anti-P2RY12 Antibody (CAB1710)Immunofluorescence analysis of mouse brain using P2RY12 antibody (CAB1710) at dilution of 1:100. Blue: DAPI for nuclear staining.

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