Anti-OXT Antibody (CAB15296)
- SKU:
- CAB15296
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Neuroscience
Frequently bought together:
Description
| Antibody Name: | Anti-OXT Antibody |
| Antibody SKU: | CAB15296 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-125 of human OXT (NP_000906.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A549, NCI-H460, LO2, HepG2, Mouse liver, Rat liver, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-125 of human OXT (NP_000906.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAGP SLAC CLLG LLAL TSAC YIQN CPLG GKRA APDL DVRK CLPC GPGG KGRC FGPN ICCA EELG CFVG TAEA LRCQ EENY LPSP CQSG QKAC GSGG RCAV LGLC CSPD GCHA DPAC DAEA TFSQ R |
| Gene ID: | 5020 |
| Uniprot: | P01178 |
| Cellular Location: | Secreted |
| Calculated MW: | 12kDa |
| Observed MW: | 13kDa |
| Synonyms: | OXT, OT, OT-NPI, OXT-NPI |
| Background: | This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. |
| UniProt Protein Function: | OXT: Neurophysin 1 specifically binds oxytocin. Belongs to the vasopressin/oxytocin family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 20p13 Cellular Component: extracellular region Biological Process: signal transduction |
| NCBI Summary: | This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. [provided by RefSeq, Dec 2013] |
| UniProt Code: | P01178 |
| NCBI GenInfo Identifier: | 128071 |
| NCBI Gene ID: | 5020 |
| NCBI Accession: | P01178.1 |
| UniProt Secondary Accession: | P01178,Q3MIG0, |
| UniProt Related Accession: | P01178 |
| Molecular Weight: | 12,722 Da |
| NCBI Full Name: | Oxytocin-neurophysin 1 |
| NCBI Synonym Full Names: | oxytocin/neurophysin I prepropeptide |
| NCBI Official Symbol: | OXT |
| NCBI Official Synonym Symbols: | OT; OT-NPI; OXT-NPI |
| NCBI Protein Information: | oxytocin-neurophysin 1 |
| UniProt Protein Name: | Oxytocin-neurophysin 1 |
| UniProt Synonym Protein Names: | OxytocinAlternative name(s):Ocytocin |
| Protein Family: | Xylosyltransferase |
| UniProt Gene Name: | OXT |
| UniProt Entry Name: | NEU1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using OXT antibody (CAB15296) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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