Anti-OXA1L Antibody (CAB6300)
- SKU:
- CAB6300
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-OXA1L Antibody |
| Antibody SKU: | CAB6300 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 396-495 of human OXA1L (NP_005006.3). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:10 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BT-474, MCF7, HepG2, A-549, 293T, Mouse kidney, Mouse liver, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 396-495 of human OXA1L (NP_005006.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PAVR TVLK IPQR VVHD LDKL PPRE GFLE SFKK GWKN AEMT RQLR EREQ RMRN QLEL AARG PLRQ TFTH NPLL QPGK DNPP NIPS SSSK PKSK YPWH DTLG |
| Gene ID: | 5018 |
| Uniprot: | Q15070 |
| Cellular Location: | Mitochondrion inner membrane, Multi-pass membrane protein |
| Calculated MW: | 28kDa/46kDa/48kDa |
| Observed MW: | 42kDa |
| Synonyms: | OXA1L, OXA1 |
| Background: | This gene encodes an evolutionarily conserved protein that is localized to the inner mitochondrial membrane. The encoded protein is essential for the translocation of the N-terminal tail of subunit 2 of cytochrome c oxidase, and is involved in the assembly of the cytochrome c oxidase and ATPase complexes of the mitochondrial respiratory chain. |
| UniProt Protein Function: | OXA1L: Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria. Belongs to the OXA1/ALB3/YidC family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Mitochondrial; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: protein complex; mitochondrion; mitochondrial membrane; mitochondrial respiratory chain Molecular Function:protein binding; protein homodimerization activity Biological Process: mitochondrial proton-transporting ATP synthase complex assembly; mitochondrial respiratory chain complex I assembly; negative regulation of oxidoreductase activity; aerobic respiration; protein complex assembly; protein insertion into membrane; negative regulation of ATPase activity; protein tetramerization |
| UniProt Code: | Q15070 |
| NCBI GenInfo Identifier: | 38372882 |
| NCBI Gene ID: | 5018 |
| NCBI Accession: | Q15070.3 |
| UniProt Secondary Accession: | Q15070,B4DPA2, |
| UniProt Related Accession: | Q15070 |
| Molecular Weight: | 435 |
| NCBI Full Name: | Mitochondrial inner membrane protein OXA1L |
| NCBI Synonym Full Names: | oxidase (cytochrome c) assembly 1-like |
| NCBI Official Symbol: | OXA1L |
| NCBI Official Synonym Symbols: | OXA1 |
| NCBI Protein Information: | mitochondrial inner membrane protein OXA1L; hsa; OXA1Hs; OXA1-like protein; oxidase assembly 1-like protein |
| UniProt Protein Name: | Mitochondrial inner membrane protein OXA1L |
| UniProt Synonym Protein Names: | Hsa; OXA1Hs; Oxidase assembly 1-like protein; OXA1-like protein |
| Protein Family: | Mitochondrial inner membrane protein |
| UniProt Gene Name: | OXA1L |
| UniProt Entry Name: | OXA1L_HUMAN |
 | Western blot analysis of extracts of various cell lines, using OXA1L antibody (CAB6300) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 60s. |
 | Immunohistochemistry of paraffin-embedded rat liver using OXA1L antibody (CAB6300) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of NIH/3T3 cells using OXA1L antibody (CAB6300) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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