Anti-OVOL2 Antibody (CAB17973)

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SKU:
CAB17973
Product type:
Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Frequently bought together:

Description

system_update_alt데이터시트system_update_alt안전 데이터시트
Antibody Name:Anti-OVOL2 Antibody
Antibody SKU:CAB17973
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human OVOL2.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse pancreas, Rat pancreas
Immunogen:Recombinant protein of human OVOL2.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:58495
Uniprot:Q9BRP0
Cellular Location:
Calculated MW:30kDa
Observed MW:30KDa
Anti-OVOL2 Antibody (CAB17973)Western blot - OVOL2 Rabbit pAb (CAB17973)
Synonyms:CHED, CHED1, CHED2, EUROIMAGE566589, PPCD1, ZNF339, OVOL2
Background:This gene encodes a member of the evolutionarily conserved ovo-like protein family. Mammalian members of this family contain a single zinc finger domain composed of a tetrad of C2H2 zinc fingers with variable N- and C-terminal extensions that contain intrinsically disordered domains. Members of this family are involved in epithelial development and differentiation. Knockout of this gene in mouse results in early embryonic lethality with phenotypes that include neurectoderm expansion, impaired vascularization, and heart anomalies. In humans, allelic variants of this gene have been associated with posterior polymorphous corneal dystrophy. [provided by RefSeq, Apr 2016]
UniProt Protein Function:OVOL2: DNA-binding protein that binds to the 5'-G[GCT]GGGGG-3' core sequence. Probably acts as a transcription regulator. Belongs to the krueppel C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA-binding; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 20p11.23

Cellular Component: nucleus

Disease: Corneal Dystrophy, Posterior Polymorphous, 1

NCBI Summary:This gene encodes a member of the evolutionarily conserved ovo-like protein family. Mammalian members of this family contain a single zinc finger domain composed of a tetrad of C2H2 zinc fingers with variable N- and C-terminal extensions that contain intrinsically disordered domains. Members of this family are involved in epithelial development and differentiation. Knockout of this gene in mouse results in early embryonic lethality with phenotypes that include neurectoderm expansion, impaired vascularization, and heart anomalies. In humans, allelic variants of this gene have been associated with posterior polymorphous corneal dystrophy. [provided by RefSeq, Apr 2016]
UniProt Code:Q9BRP0
NCBI GenInfo Identifier:743405586
NCBI Gene ID:58495
NCBI Accession:NP_001290390.1
UniProt Secondary Accession:Q9BRP0,Q5T8B4, Q9BX22, Q9HA54, Q9Y4M0,
UniProt Related Accession:Q9BRP0
Molecular Weight:16,565 Da
NCBI Full Name:transcription factor Ovo-like 2 isoform 2
NCBI Synonym Full Names:ovo like zinc finger 2
NCBI Official Symbol:OVOL2  
NCBI Official Synonym Symbols:PPCD1; ZNF339; EUROIMAGE566589  
NCBI Protein Information:transcription factor Ovo-like 2
UniProt Protein Name:Transcription factor Ovo-like 2
UniProt Synonym Protein Names:Zinc finger protein 339
Protein Family:Transcription factor
UniProt Gene Name:OVOL2  
UniProt Entry Name:OVOL2_HUMAN

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