| Background: | This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. |
| UniProt Protein Function: | OVGP1: Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development. Belongs to the glycosyl hydrolase 18 family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1p13 Cellular Component: transport vesicle; extracellular region; cytosol Molecular Function:chitin binding; chitinase activity Biological Process: binding of sperm to zona pellucida; single fertilization; carbohydrate metabolic process; chitin catabolic process; female pregnancy; multicellular organism reproduction |
| NCBI Summary: | This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q12889 |
| NCBI GenInfo Identifier: | 58386720 |
| NCBI Gene ID: | 5016 |
| NCBI Accession: | NP_002548.3 |
| UniProt Secondary Accession: | Q12889,Q15841, A0AV19, B9EGE1, |
| UniProt Related Accession: | Q12889 |
| Molecular Weight: | 75,421 Da |
| NCBI Full Name: | oviduct-specific glycoprotein |
| NCBI Synonym Full Names: | oviductal glycoprotein 1, 120kDa |
| NCBI Official Symbol: | OVGP1 |
| NCBI Official Synonym Symbols: | EGP; OGP; MUC9; CHIT5 |
| NCBI Protein Information: | oviduct-specific glycoprotein; estrogen-dependent oviduct protein; mucin 9; mucin-9; oviduct glycoprotein; oviductin |
| UniProt Protein Name: | Oviduct-specific glycoprotein |
| UniProt Synonym Protein Names: | Estrogen-dependent oviduct protein; Mucin-9; Oviductal glycoprotein; Oviductin |
| UniProt Gene Name: | OVGP1 |
| UniProt Entry Name: | OVGP1_HUMAN |
