Anti-OSGIN1 Antibody (CAB15826)
- SKU:
- CAB15826
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| Antibody Name: | Anti-OSGIN1 Antibody |
| Antibody SKU: | CAB15826 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human OSGIN1 (NP_892026.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human OSGIN1 (NP_892026.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSSS RKDH LGAS SSEP LPVI IVGN GPSG ICLS YLLS GYTP YTKP DAIH PHPL LQRK LTEA PGVS ILDQ DLDY LSEG LEGR SQSP VALL FDAL LRPD TDFG GNMK SVLT WKHR KEHA IPHV VLGR NLPG GAWH SIEG SMVI LSQG QWMG LPDL EVKD WMQK KRRG LRNS RATA GDIA HYYR DYVV KKGL GHNF VSGA VVTA |
| Gene ID: | 29948 |
| Uniprot: | Q9UJX0 |
| Cellular Location: | |
| Calculated MW: | 51kDa/60kDa |
| Observed MW: | 75kDa |
| Synonyms: | OSGIN1, BDGI, OKL38 |
| Background: | This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. |
| UniProt Protein Function: | OSGIN1: Regulates the differentiation and proliferation of normal cells through the regulation of cell death. Belongs to the OKL38 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 16q23.3 Molecular Function:growth factor activity; protein binding Biological Process: negative regulation of cell growth |
| NCBI Summary: | This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q9UJX0 |
| NCBI GenInfo Identifier: | 334302887 |
| NCBI Gene ID: | 29948 |
| NCBI Accession: | Q9UJX0.3 |
| UniProt Secondary Accession: | Q9UJX0,Q52M33, Q86UQ1, Q96S88, Q9BZ70, |
| UniProt Related Accession: | Q9UJX0 |
| Molecular Weight: | – Da |
| NCBI Full Name: | Oxidative stress-induced growth inhibitor 1 |
| NCBI Synonym Full Names: | oxidative stress induced growth inhibitor 1 |
| NCBI Official Symbol: | OSGIN1 |
| NCBI Official Synonym Symbols: | BDGI; OKL38 |
| NCBI Protein Information: | oxidative stress-induced growth inhibitor 1 |
| UniProt Protein Name: | Oxidative stress-induced growth inhibitor 1 |
| UniProt Synonym Protein Names: | Ovary, kidney and liver protein 38; huOKL38; Pregnancy-induced growth inhibitor OKL38 |
| Protein Family: | Oxidative stress-induced growth inhibitor |
| UniProt Gene Name: | OSGIN1 |
| UniProt Entry Name: | OSGI1_HUMAN |
 | Western blot analysis of extracts of 293T cells, using OSGIN1 antibody (CAB15826) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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