Anti-OPTC Antibody (CAB16514)
- SKU:
- CAB16514
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-OPTC Antibody |
| Antibody SKU: | CAB16514 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-115 of human OPTC (NP_055174.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse liver, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-115 of human OPTC (NP_055174.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ASLP RKER KRRE EQMP REGD SFEV LPLR NDVL NPDN YGEV IDLS NYEE LTDY GDQL PEVK VTSL APAT SISP AKST TAPG TPSS NPTM TRPT TAGL |
| Gene ID: | 26254 |
| Uniprot: | Q9UBM4 |
| Cellular Location: | Secreted, extracellular matrix, extracellular space |
| Calculated MW: | 37kDa |
| Observed MW: | 54kDa |
| Synonyms: | OPTC, OPT, opticin |
| Background: | Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1). |
| UniProt Protein Function: | OPTC: Binds collagen fibrils. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: proteinaceous extracellular matrix Molecular Function:extracellular matrix structural constituent Biological Process: negative regulation of angiogenesis |
| NCBI Summary: | Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1). [provided by RefSeq] |
| UniProt Code: | Q9UBM4 |
| NCBI GenInfo Identifier: | 5777529 |
| NCBI Gene ID: | 26254 |
| NCBI Accession: | |
| UniProt Secondary Accession: | Q9UBM4,Q5T2G4, |
| UniProt Related Accession: | Q9UBM4 |
| Molecular Weight: | 37,261 Da |
| NCBI Full Name: | opticin |
| NCBI Synonym Full Names: | opticin |
| NCBI Official Symbol: | OPTC |
| NCBI Official Synonym Symbols: | OPT; OPTC |
| NCBI Protein Information: | opticin; oculoglycan |
| UniProt Protein Name: | Opticin |
| UniProt Synonym Protein Names: | Oculoglycan |
| Protein Family: | Opticin |
| UniProt Gene Name: | OPTC |
| UniProt Entry Name: | OPT_HUMAN |
 | Western blot analysis of extracts of various cell lines, using OPTC antibody (CAB16514) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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