| UniProt Protein Function: | OLIG2: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA. |
| UniProt Protein Details: | Protein type:Transcription factor; Oncoprotein Chromosomal Location of Human Ortholog: 21q22.11 |
| NCBI Summary: | This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13516 |
| NCBI GenInfo Identifier: | 22261817 |
| NCBI Gene ID: | 10215 |
| NCBI Accession: | Q13516.2 |
| UniProt Secondary Accession: | Q13516,Q05BP9, Q49AL3, Q86X04, Q9NZ14, B3KRF3, |
| UniProt Related Accession: | Q13516 |
| Molecular Weight: | 32,385 Da |
| NCBI Full Name: | Oligodendrocyte transcription factor 2 |
| NCBI Synonym Full Names: | oligodendrocyte lineage transcription factor 2 |
| NCBI Official Symbol: | OLIG2 |
| NCBI Official Synonym Symbols: | BHLHB1; OLIGO2; RACK17; PRKCBP2; bHLHe19 |
| NCBI Protein Information: | oligodendrocyte transcription factor 2 |
| UniProt Protein Name: | Oligodendrocyte transcription factor 2 |
| UniProt Synonym Protein Names: | Class B basic helix-loop-helix protein 1; bHLHb1; Class E basic helix-loop-helix protein 19; bHLHe19; Protein kinase C-binding protein 2; Protein kinase C-binding protein RACK17 |
| Protein Family: | Oligodendrocyte transcription factor |
| UniProt Gene Name: | OLIG2 |
| UniProt Entry Name: | OLIG2_HUMAN |
