Anti-ODC1 Antibody (CAB1948)
- SKU:
- CAB1948
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-ODC1 Antibody |
| Antibody SKU: | CAB1948 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ODC1 (NP_002530.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, THP-1, Mouse kidney, Mouse skeletal muscle |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ODC1 (NP_002530.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MNNF GNEE FDCH FLDE GFTA KDIL DQKI NEVS SSDD KDAF YVAD LGDI LKKH LRWL KALP RVTP FYAV KCND SKAI VKTL AATG TGFD CASK TEIQ LVQS LGVP PERI IYAN PCKQ VSQI KYAA NNGV QMMT FDSE VELM KVAR AHPK AKLV LRIA TDDS KAVC RLSV KFGA TLRT SRLL LERA KELN IDVV GVSF HVGS GCTD PETF VQAI SDAR CVFD MGAE VGFS MYLL DIGG GFPG SEDV KLKF EEIT GVIN PALD KYFP SDSG VRII AEPG RYYV |
| Gene ID: | 4953 |
| Uniprot: | P11926 |
| Cellular Location: | |
| Calculated MW: | 51kDa |
| Observed MW: | 51kDa |
| Synonyms: | ODC, ODC1 |
| Background: | This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. |
| UniProt Protein Function: | ODC: the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Other Amino Acids Metabolism - glutathione; EC 4.1.1.17; Cell cycle regulation; Lyase; Amino Acid Metabolism - arginine and proline Chromosomal Location of Human Ortholog: 2p25 Cellular Component: cytoplasm; cytosol Molecular Function:ornithine decarboxylase activity; protein binding; protein homodimerization activity Biological Process: polyamine metabolic process; putrescine biosynthetic process from ornithine; regulation of amino acid metabolic process; regulation of protein catabolic process; response to virus Disease: Colorectal Cancer |
| NCBI Summary: | This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013] |
| UniProt Code: | P11926 |
| NCBI GenInfo Identifier: | 118377 |
| NCBI Gene ID: | 4953 |
| NCBI Accession: | P11926.2 |
| UniProt Secondary Accession: | P11926,Q53TU3, Q6LDS9, |
| UniProt Related Accession: | P11926 |
| Molecular Weight: | 51,148 Da |
| NCBI Full Name: | Ornithine decarboxylase |
| NCBI Synonym Full Names: | ornithine decarboxylase 1 |
| NCBI Official Symbol: | ODC1 |
| NCBI Official Synonym Symbols: | ODC |
| NCBI Protein Information: | ornithine decarboxylase |
| UniProt Protein Name: | Ornithine decarboxylase |
| Protein Family: | Mitochondrial 2-oxodicarboxylate carrier |
| UniProt Gene Name: | ODC1 |
| UniProt Entry Name: | DCOR_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ODC1 antibody (CAB1948) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded rat islets of langerhans using ODC1 antibody (CAB1948) at dilution of 1:100 (40x lens). |
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