Anti-NUDEL Antibody (CAB3799)
- SKU:
- CAB3799
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Description
Antibody Name: | Anti-NUDEL Antibody |
Antibody SKU: | CAB3799 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | A synthesized peptide derived from human NUDEL |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | HepG2, A-549, U-87MG, Mouse lung, Mouse brain, Rat brain, Rat heart |
Immunogen: | A synthesized peptide derived from human NUDEL |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 81565 |
Uniprot: | Q9GZM8 |
Cellular Location: | |
Calculated MW: | 40kDa |
Observed MW: | 40KDa |
Synonyms: | EOPA, MITAP1, NDE1L1, NDE2, NUDEL |
Background: | This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Mar 2012] |
UniProt Protein Function: | NDEL1: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Belongs to the nudE family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Protease; Microtubule-binding Chromosomal Location of Human Ortholog: 17p13.1 Cellular Component: axon hillock; kinetochore; microtubule; kinesin complex; centrosome; neurofilament cytoskeleton; cytoplasm; leading edge; nucleolus; nuclear envelope; spindle; cytosol Molecular Function:protein binding; microtubule binding; beta-tubulin binding; alpha-tubulin binding Biological Process: cell migration; positive regulation of axon regeneration; central nervous system neuron axonogenesis; positive regulation of axon extension; establishment of chromosome localization; neuron migration; nuclear envelope disassembly; proteolysis; microtubule nucleation; inner cell mass cell proliferation; retrograde axon cargo transport; chromosome segregation; mitotic centrosome separation; establishment of mitotic spindle orientation; centrosome localization; neurofilament cytoskeleton organization and biogenesis; vesicle transport along microtubule; cerebral cortex radially oriented cell migration; mitotic cell cycle |
NCBI Summary: | This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Mar 2012] |
UniProt Code: | Q9GZM8 |
NCBI GenInfo Identifier: | 74725006 |
NCBI Gene ID: | 81565 |
NCBI Accession: | Q9GZM8.1 |
UniProt Secondary Accession: | Q9GZM8,Q86T80, Q8TAR7, Q9UH50, B3KP93, D3DTS0, J3QT32 |
UniProt Related Accession: | Q9GZM8 |
Molecular Weight: | 345 |
NCBI Full Name: | Nuclear distribution protein nudE-like 1 |
NCBI Synonym Full Names: | nudE neurodevelopment protein 1-like 1 |
NCBI Official Symbol: | NDEL1 |
NCBI Official Synonym Symbols: | EOPA; NDE2; NUDEL; MITAP1; NDE1L1 |
NCBI Protein Information: | nuclear distribution protein nudE-like 1; protein Nudel; endooligopeptidase A; mitosin-associated protein 1; mitosin-associated protein MITAP1; nudE nuclear distribution E homolog-like 1; nudE nuclear distribution gene E homolog-like 1 |
UniProt Protein Name: | Nuclear distribution protein nudE-like 1 |
UniProt Synonym Protein Names: | Mitosin-associated protein 1 |
UniProt Gene Name: | NDEL1 |
UniProt Entry Name: | NDEL1_HUMAN |