Anti-NTS Antibody (CAB12012)
- SKU:
- CAB12012
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-NTS Antibody |
| Antibody SKU: | CAB12012 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-148 of human NTS (NP_006174.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-148 of human NTS (NP_006174.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SDSE EEMK ALEA DFLT NMHT SKIS KAHV PSWK MTLL NVCS LVNN LNSP AEET GEVH EEEL VARR KLPT ALDG FSLE AMLT IYQL HKIC HSRA FQHW ELIQ EDIL DTGN DKNG KEEV IKRK IPYI L |
| Gene ID: | 4922 |
| Uniprot: | P30990 |
| Cellular Location: | Cytoplasmic vesicle, Secreted, secretory vesicle |
| Calculated MW: | 19kDa |
| Observed MW: | 20kDa |
| Synonyms: | NTS, NMN-125, NN, NT, NT/N, NTS1 |
| Background: | This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Neurotensin also exhibits antimicrobial activity against bacteria and fungi. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. |
| UniProt Protein Function: | NTS: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle. Belongs to the neurotensin family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 12q21.31 Cellular Component: extracellular region; nerve terminal Molecular Function:neuropeptide hormone activity |
| NCBI Summary: | This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Neurotensin also exhibits antimicrobial activity against bacteria and fungi. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. [provided by RefSeq, Oct 2014] |
| UniProt Code: | P30990 |
| NCBI GenInfo Identifier: | 2828196 |
| NCBI Gene ID: | 4922 |
| NCBI Accession: | P30990.2 |
| UniProt Related Accession: | P30990 |
| Molecular Weight: | 20kDa |
| NCBI Full Name: | Neurotensin/neuromedin N |
| NCBI Synonym Full Names: | neurotensin |
| NCBI Official Symbol: | NTS |
| NCBI Official Synonym Symbols: | NN; NT; NT/N; NTS1; NMN-125 |
| NCBI Protein Information: | neurotensin/neuromedin N |
| UniProt Protein Name: | Neurotensin/neuromedin N |
| UniProt Synonym Protein Names: | Large neuromedin NAlternative name(s):NmN-125 |
| Protein Family: | Neurotensin |
| UniProt Gene Name: | NTS |
 | Western blot analysis of extracts of 293T cells, using NTS antibody (CAB12012) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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