Anti-NTN1 Antibody (CAB16236)
- SKU:
- CAB16236
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-NTN1 Antibody |
| Antibody SKU: | CAB16236 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 500-600 of human NTN1 (NP_004813.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Rat brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 500-600 of human NTN1 (NP_004813.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | HILK ADKA GDWW KFTV NIIS VYKQ GTSR IRRG DQSL WIRS RDIA CKCP KIKP LKKY LLLG NAED SPDQ SGIV ADKS SLVI QWRD TWAR RLRK FQQR EKKG K |
| Gene ID: | 9423 |
| Uniprot: | O95631 |
| Cellular Location: | |
| Calculated MW: | 67kDa |
| Observed MW: | 68kDa |
| Synonyms: | NTN1, NTN1L, netrin-1 |
| Background: | Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. |
| UniProt Protein Function: | NTN1: Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 17p13.1 Cellular Component: extracellular region Molecular Function:protein binding Biological Process: axon guidance; Cdc42 protein signal transduction; positive regulation of axon extension; Ras protein signal transduction; substrate-bound cell migration, cell extension |
| NCBI Summary: | Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95631 |
| NCBI GenInfo Identifier: | 229462906 |
| NCBI Gene ID: | 9423 |
| NCBI Accession: | O95631.2 |
| UniProt Secondary Accession: | O95631,E9KL51, |
| UniProt Related Accession: | O95631 |
| Molecular Weight: | 67,748 Da |
| NCBI Full Name: | Netrin-1 |
| NCBI Synonym Full Names: | netrin 1 |
| NCBI Official Symbol: | NTN1 |
| NCBI Official Synonym Symbols: | NTN1L |
| NCBI Protein Information: | netrin-1 |
| UniProt Protein Name: | Netrin-1 |
| UniProt Synonym Protein Names: | Epididymis tissue protein Li 131P |
| Protein Family: | Netrin |
| UniProt Gene Name: | NTN1 |
| UniProt Entry Name: | NET1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NTN1 antibody (CAB16236) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3min. |
Related Products
