Anti-NTF3 Antibody (CAB12476)
- SKU:
- CAB12476
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NTF3 Antibody |
| Antibody SKU: | CAB12476 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-257 of human NTF3 (NP_002518.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Jurkat, SW480, SKOV3, MCF7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-257 of human NTF3 (NP_002518.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NNMD QRSL PEDS LNSL IIKL IQAD ILKN KLSK QMVD VKEN YQST LPKA EAPR EPER GGPA KSAF QPVI AMDT ELLR QQRR YNSP RVLL SDST PLEP PPLY LMED YVGS PVVA NRTS RRKR YAEH KSHR GEYS VCDS ESLW VTDK SSAI DIRG HQVT VLGE IKTG NSPV KQYF YETR CKEA RPVK NGCR GIDD KHWN SQCK TSQT YVRA LTSE NNKL VGWR WIRI DTSC VCAL SRKI GRT |
| Gene ID: | 4908 |
| Uniprot: | P20783 |
| Cellular Location: | Secreted |
| Calculated MW: | 29kDa/30kDa |
| Observed MW: | 36kDa |
| Synonyms: | NTF3, HDNF, NGF-2, NGF2, NT-3, NT3 |
| Background: | The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. |
| UniProt Protein Function: | NT-3: Seems to promote the survival of visceral and proprioceptive sensory neurons. Belongs to the NGF-beta family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytokine; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 12p13 Cellular Component: cytoplasmic membrane-bound vesicle; extracellular region Molecular Function:neurotrophin p75 receptor binding; growth factor activity; nerve growth factor binding; receptor binding; chemoattractant activity Biological Process: myelination; axon guidance; mechanoreceptor differentiation; epidermis development; glial cell fate determination; activation of MAPK activity; regulation of neuron differentiation; positive regulation of receptor internalization; positive regulation of glial cell differentiation; signal transduction; enteric nervous system development; induction of positive chemotaxis; positive chemotaxis; cell-cell signaling; positive regulation of cell proliferation; negative regulation of neuron apoptosis; regulation of synaptic transmission; negative regulation of peptidyl-tyrosine phosphorylation; nervous system development; activation of protein kinase B; positive regulation of peptidyl-serine phosphorylation; peripheral nervous system development; positive regulation of peptidyl-tyrosine phosphorylation; neuromuscular synaptic transmission; nerve development; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; brain development; transmembrane receptor protein tyrosine kinase signaling pathway; neurite morphogenesis; positive regulation of cell migration |
| NCBI Summary: | The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P20783 |
| NCBI GenInfo Identifier: | 128581 |
| NCBI Gene ID: | 4908 |
| NCBI Accession: | P20783.1 |
| UniProt Secondary Accession: | P20783,Q6FH50, B7Z1T5, |
| UniProt Related Accession: | P20783 |
| Molecular Weight: | 30,800 Da |
| NCBI Full Name: | Neurotrophin-3 |
| NCBI Synonym Full Names: | neurotrophin 3 |
| NCBI Official Symbol: | NTF3 |
| NCBI Official Synonym Symbols: | NT3; HDNF; NGF2; NT-3; NGF-2 |
| NCBI Protein Information: | neurotrophin-3; neurotrophic factor; nerve growth factor 2 |
| UniProt Protein Name: | Neurotrophin-3 |
| UniProt Synonym Protein Names: | HDNF; Nerve growth factor 2; NGF-2; Neurotrophic factor |
| Protein Family: | Neurotrophin |
| UniProt Gene Name: | NTF3 |
| UniProt Entry Name: | NTF3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NTF3 antibody (CAB12476) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded mouse brain using NTF3 antibody (CAB12476) (40x lens). |
 | Immunohistochemistry of paraffin-embedded human liver damage using NTF3 antibody (CAB12476) (40x lens). |
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