Anti-NT5E Antibody (CAB16936)
- SKU:
- CAB16936
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NT5E Antibody |
| Antibody SKU: | CAB16936 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human NT5E. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse lung, Rat liver |
| Immunogen: | Recombinant protein of human NT5E. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4907 |
| Uniprot: | P21589 |
| Cellular Location: | Cell membrane, GPI-anchor, Lipid-anchor |
| Calculated MW: | 57kDa/63kDa |
| Observed MW: | 70kDa |
 | Western blot - NT5E Rabbit pAb (CAB16936) |
| Synonyms: | NT5E, CALJA, CD73, E5NT, NT, NT5, NTE, eN, eNT |
| Background: | The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | NT5E: Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Homodimer; disulfide-linked. Belongs to the 5'-nucleotidase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.1.3.5; Membrane protein, integral; Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine; Phosphatase (non-protein); Membrane protein, GPI anchor; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide Chromosomal Location of Human Ortholog: 6q14-q21 Cellular Component: cell surface; membrane; cytoplasm; plasma membrane Molecular Function:5'-nucleotidase activity; metal ion binding; nucleotide binding Biological Process: pyrimidine nucleoside catabolic process; dephosphorylation; pyrimidine base metabolic process; nucleobase, nucleoside and nucleotide metabolic process; adenosine biosynthetic process; negative regulation of inflammatory response; purine nucleotide catabolic process; DNA metabolic process; purine base metabolic process; AMP catabolic process Disease: Calcification Of Joints And Arteries |
| NCBI Summary: | The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011] |
| UniProt Code: | P21589 |
| NCBI GenInfo Identifier: | 112825 |
| NCBI Gene ID: | 4907 |
| NCBI Accession: | P21589.1 |
| UniProt Related Accession: | P21589 |
| Molecular Weight: | |
| NCBI Full Name: | 5'-nucleotidase |
| NCBI Synonym Full Names: | 5'-nucleotidase ecto |
| NCBI Official Symbol: | NT5E |
| NCBI Official Synonym Symbols: | NT; eN; NT5; NTE; eNT; CD73; E5NT; CALJA |
| NCBI Protein Information: | 5'-nucleotidase |
| UniProt Protein Name: | 5'-nucleotidase |
| UniProt Synonym Protein Names: | Ecto-5'-nucleotidase; CD_antigen: CD73 |
| UniProt Gene Name: | NT5E |
| UniProt Entry Name: | 5NTD_HUMAN |
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