| UniProt Protein Function: | NRCAM: Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier. Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. 5 isoforms of the human protein are produced by alternative splicing.Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 7q31Cellular Component: plasma membraneMolecular Function: ankyrin binding; protein bindingBiological Process: angiogenesis; clustering of voltage-gated sodium channels; synaptogenesis |
| UniProt Protein Details: | |
| NCBI Summary: | Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q92823 |
| NCBI GenInfo Identifier: | 215274127 |
| NCBI Gene ID: | 4897 |
| NCBI Accession: | Q92823.3 |
| UniProt Secondary Accession: | Q92823,O15051, O15179, Q14BM2, Q9UHI3, Q9UHI4, A4D0S3 E9PDA4 |
| UniProt Related Accession: | Q92823 |
| Molecular Weight: | 131,744 Da |
| NCBI Full Name: | Neuronal cell adhesion molecule |
| NCBI Synonym Full Names: | neuronal cell adhesion molecule |
| NCBI Official Symbol: | NRCAM |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | neuronal cell adhesion molecule |
| UniProt Protein Name: | Neuronal cell adhesion molecule |
| UniProt Synonym Protein Names: | Neuronal surface protein Bravo |
| Protein Family: | Neuronal cell adhesion molecule |
| UniProt Gene Name: | NRCAM |
| UniProt Entry Name: | NRCAM_HUMAN |
