Anti-NRAS Antibody (CAB7566)
- SKU:
- CAB7566
- Product type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- NRAS
- ALPS4
- CMNS
- N-ras
- NCMS
- NRAS1
- NS6
Frequently bought together:
Description
Product Name: | NRAS Rabbit pAb |
Product Code: | CAB7566 |
Size: | 20uL, 50uL, 100uL |
Synonyms: | NRAS, ALPS4, CMNS, N-ras, NCMS, NRAS1, NS6 |
Applications: | WB, IF |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-189 of human NRAS (NP_002515.1). |
Applications: | WB, IF |
Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | 293T, Jurkat, Mouse brain |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-189 of human NRAS (NP_002515.1). |
Purification Method: | Affinity purification |
Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | MTEY KLVV VGAG GVGK SALT IQLI QNHF VDEY DPTI EDSY RKQV VIDG ETCL LDIL DTAG QEEY SAMR DQYM RTGE GFLC VFAI NNSK SFAD INLY REQI KRVK DSDD VPMV LVGN KCDL PTRT VDTK QAHE LAKS YGIP FIET SAKT RQGV EDAF YTLV REIR QYRM KKLN SSDD GTQG CMGL PCVV M |
Gene ID: | 4893 |
Uniprot: | P01111 |
Cellular Location: | Cell membrane, Cytoplasmic side, Golgi apparatus membrane, Lipid-anchor |
Calculated MW: | 21kDa |
Observed MW: | 21KDa |
UniProt Protein Function: | NRas: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Interacts (active GTP-bound form preferentially) with RGS14. Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP). Belongs to the small GTPase superfamily. Ras family. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Oncoprotein; G protein, monomeric; G protein; G protein, monomeric, Ras Chromosomal Location of Human Ortholog: 1p13.2 Cellular Component: Golgi apparatus; membrane; plasma membrane Molecular Function:protein complex binding Biological Process: axon guidance; epidermal growth factor receptor signaling pathway; leukocyte migration; MAPKKK cascade; Ras protein signal transduction; stimulatory C-type lectin receptor signaling pathway Disease: Colorectal Cancer; Melanocytic Nevus Syndrome, Congenital; Melanosis, Neurocutaneous; Nevus, Epidermal; Noonan Syndrome 6; Ras-associated Autoimmune Leukoproliferative Disorder; Schimmelpenning-feuerstein-mims Syndrome; Thyroid Carcinoma, Follicular |
NCBI Summary: | This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011] |
UniProt Code: | P01111 |
NCBI GenInfo Identifier: | 131883 |
NCBI Gene ID: | 4893 |
NCBI Accession: | P01111.1 |
UniProt Secondary Accession: | P01111,Q14971, Q15104, Q15282, |
UniProt Related Accession: | P01111 |
Molecular Weight: | 21,229 Da |
NCBI Full Name: | GTPase NRas |
NCBI Synonym Full Names: | neuroblastoma RAS viral oncogene homolog |
NCBI Official Symbol: | NRAS |
NCBI Official Synonym Symbols: | NS6; CMNS; NCMS; ALPS4; N-ras; NRAS1 |
NCBI Protein Information: | GTPase NRas |
UniProt Protein Name: | GTPase NRas |
UniProt Synonym Protein Names: | Transforming protein N-Ras |
Protein Family: | GTPase |
UniProt Gene Name: | NRAS |
UniProt Entry Name: | RASN_HUMAN |