Anti-NPY Antibody (CAB3178)
- SKU:
- CAB3178
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-NPY Antibody |
| Antibody SKU: | CAB3178 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-97 of human NPY (NP_000896.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-97 of human NPY (NP_000896.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MLGN KRLG LSGL TLAL SLLV CLGA LAEA YPSK PDNP GEDA PAED MARY YSAL RHYI NLIT RQRY GKRS SPET LISD LLMR ESTE NVPR TRLE DPAM W |
| Gene ID: | 4852 |
| Uniprot: | P01303 |
| Cellular Location: | Secreted |
| Calculated MW: | 10kDa |
| Observed MW: | 11KDa |
| Synonyms: | NPY, PYY4 |
| Background: | This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. |
| UniProt Protein Function: | NPY: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. Belongs to the NPY family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Hormone Chromosomal Location of Human Ortholog: 7p15.1 Cellular Component: Golgi apparatus; extracellular space; cell; extracellular region Molecular Function:G-protein coupled receptor activity; neuropeptide hormone activity; neuropeptide Y receptor binding; calcium channel regulator activity; receptor binding Biological Process: blood circulation; behavior; adult feeding behavior; G-protein signaling, coupled to cyclic nucleotide second messenger; synaptic transmission; cell proliferation; neuropeptide signaling pathway; regulation of blood pressure; calcium ion transport; positive regulation of appetite; regulation of appetite; digestion; feeding behavior; cerebral cortex development; cell motility; neurite development; central nervous system neuron development |
| NCBI Summary: | This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014] |
| UniProt Code: | P01303 |
| NCBI GenInfo Identifier: | 128117 |
| NCBI Gene ID: | 4852 |
| NCBI Accession: | P01303.1 |
| UniProt Related Accession: | P01303 |
| Molecular Weight: | 10 kDa |
| NCBI Full Name: | Pro-neuropeptide Y |
| NCBI Synonym Full Names: | neuropeptide Y |
| NCBI Official Symbol: | NPY |
| NCBI Official Synonym Symbols: | PYY4 |
| NCBI Protein Information: | pro-neuropeptide Y; prepro-neuropeptide Y |
| UniProt Protein Name: | Pro-neuropeptide Y |
| UniProt Synonym Protein Names: | Neuropeptide tyrosine; NPY |
| Protein Family: | Neuropeptide |
| UniProt Gene Name: | NPY |
| UniProt Entry Name: | NPY_HUMAN |
 | Western blot analysis of extracts of SH-SY5Y cells, using NPY antibody (CAB3178) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
 | Immunohistochemistry of paraffin-embedded mouse spinal cord using NPY Rabbit pAb (CAB3178) at dilution of 1:100 (40x lens). |
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