Anti-NPHS2 Antibody (CAB2302)
- SKU:
- CAB2302
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- PDCN
- SRN1
Frequently bought together:
Description
| Product Name: | NPHS2 Rabbit mAb |
| Product Code: | CAB2302 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | PDCN, SRN1 |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human NPHS2 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HeLa, HT-29, 293T |
| Immunogen: | A synthesized peptide derived from human NPHS2 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 7827 |
| Uniprot: | Q9NP85 |
| Calculated MW: | 42kDa |
| Observed MW: | 35KDa |
| UniProt Protein Function: | NPHS2: Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton. Defects in NPHS2 are the cause of nephrotic syndrome type 2 (NPHS2). It is a renal disorder characterized clinically by childhood onset of proteinuria, hypoalbuminemia, hyperlipidemia, and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. The disorder is resistant to steroid treatment and progresses to end-stage renal failure in the first or second decades. Some patients show later onset of the disorder. Belongs to the band 7/mec-2 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 1q25.2 Cellular Component: protein complex; integral to plasma membrane; endoplasmic reticulum; plasma membrane; intercellular junction; lipid raft Molecular Function:protein binding Biological Process: actin cytoskeleton reorganization; excretion Disease: Nephrotic Syndrome, Type 2 |
| NCBI Summary: | This gene encodes a protein that plays a role in the regulation of glomerular permeability. Mutations in this gene cause steroid-resistant nephrotic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| UniProt Code: | Q9NP85 |
| NCBI GenInfo Identifier: | 12230467 |
| NCBI Gene ID: | 7827 |
| NCBI Accession: | Q9NP85.1 |
| UniProt Secondary Accession: | Q9NP85,Q8N6Q5, B1AM32, B1AM33, |
| UniProt Related Accession: | Q9NP85 |
| Molecular Weight: | 34,421 Da |
| NCBI Full Name: | Podocin |
| NCBI Synonym Full Names: | nephrosis 2, idiopathic, steroid-resistant (podocin) |
| NCBI Official Symbol: | NPHS2 |
| NCBI Official Synonym Symbols: | PDCN; SRN1 |
| NCBI Protein Information: | podocin |
| UniProt Protein Name: | Podocin |
| Protein Family: | Podocin |
| UniProt Gene Name: | NPHS2 |
| UniProt Entry Name: | PODO_HUMAN |
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